Top ▲

Interleukin-17 receptor D

Click here for help

Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1741

Nomenclature: Interleukin-17 receptor D

Family: IL-17 receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 739 3p14.3 IL17RD interleukin 17 receptor D
Mouse 1 738 14 A3 Il17rd interleukin 17 receptor D
Rat - - Il17rd interleukin 17 receptor D
Previous and Unofficial Names Click here for help
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
Immunopharmacology Comments
IL17RD acts as an inhibitor of proinflammatory cytokine signaling (by limiting NF-κB translocation to the nucleus) [1], and has been reported as a feedback antagonist of receptor tyrosine kinase (RTK) signaling [3], and as a tumor suppressor gene [2,4].
Immuno Process Associations
Immuno Process:  Cytokine production & signalling


Show »

1. Fuchs Y, Brunwasser M, Haif S, Haddad J, Shneyer B, Goldshmidt-Tran O, Korsensky L, Abed M, Zisman-Rozen S, Koren L et al.. (2012) Sef is an inhibitor of proinflammatory cytokine signaling, acting by cytoplasmic sequestration of NF-κB. Dev Cell, 23 (3): 611-23. [PMID:22975329]

2. Murphy T, Darby S, Mathers ME, Gnanapragasam VJ. (2010) Evidence for distinct alterations in the FGF axis in prostate cancer progression to an aggressive clinical phenotype. J Pathol, 220 (4): 452-60. [PMID:19960500]

3. Ron D, Fuchs Y, Chorev DS. (2008) Know thy Sef: a novel class of feedback antagonists of receptor tyrosine kinase signaling. Int J Biochem Cell Biol, 40 (10): 2040-52. [PMID:18450498]

4. Zisman-Rozen S, Fink D, Ben-Izhak O, Fuchs Y, Brodski A, Kraus MH, Bejar J, Ron D. (2007) Downregulation of Sef, an inhibitor of receptor tyrosine kinase signaling, is common to a variety of human carcinomas. Oncogene, 26 (41): 6093-8. [PMID:17420726]

How to cite this page

IL-17 receptor family: Interleukin-17 receptor D. Last modified on 07/04/2017. Accessed on 24/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY,