Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	655	6p12.3	TNFRSF21	TNF receptor superfamily member 21
Mouse	1	655	17 B3	Tnfrsf21	tumor necrosis factor receptor superfamily, member 21
Rat	-	-		Tnfrsf21	TNF receptor superfamily member 21

Previous and Unofficial Names

tumor necrosis factor receptor superfamily, member 21 | CD358 | tumor necrosis factor receptor superfamily

Database Links
Alphafold	O75509 (Hs), Q9EPU5 (Mm)
Ensembl Gene	ENSG00000146072 (Hs), ENSMUSG00000023915 (Mm), ENSRNOG00000011517 (Rn)
Entrez Gene	27242 (Hs), 94185 (Mm), 316256 (Rn)
Human Protein Atlas	ENSG00000146072 (Hs)
KEGG Gene	hsa:27242 (Hs), mmu:94185 (Mm), rno:316256 (Rn)
OMIM	605732 (Hs)
Pharos	O75509 (Hs)
UniProtKB	O75509 (Hs), Q9EPU5 (Mm)
Wikipedia	TNFRSF21 (Hs)

Adaptor proteins (Human)

TRADD

Immunopharmacology Comments

Expressed predominantly in the thymus, spleen and white blood cells. May play a role in T helper cell activation, inflammation and immune regulation. Signals via the TRADD adaptor protein to the NF-κB and MAPK8/JNK pathways.

Immuno Process Associations

Immuno Process:  T cell (activation) GO Annotations:  Associated to 2 GO processes GO:0002250 adaptive immune response ISS GO:0042130 negative regulation of T cell proliferation ISS

Immuno Process:  B cell (activation) GO Annotations:  Associated to 3 GO processes GO:0001783 B cell apoptotic process ISS GO:0002250 adaptive immune response ISS GO:0030889 negative regulation of B cell proliferation ISS

Immuno Process:  Immune regulation GO Annotations:  Associated to 3 GO processes GO:0030889 negative regulation of B cell proliferation ISS GO:0042130 negative regulation of T cell proliferation ISS GO:0050852 T cell receptor signaling pathway ISS

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 4 GO processes GO:0032693 negative regulation of interleukin-10 production ISS GO:0032696 negative regulation of interleukin-13 production ISS GO:0032714 negative regulation of interleukin-5 production ISS GO:0071356 cellular response to tumor necrosis factor IDA

Immuno Process:  Chemotaxis & migration GO Annotations:  Associated to 1 GO processes GO:0042130 negative regulation of T cell proliferation ISS

Immuno Process:  Cellular signalling GO Annotations:  Associated to 3 GO processes GO:0030889 negative regulation of B cell proliferation ISS GO:0042130 negative regulation of T cell proliferation ISS GO:0050852 T cell receptor signaling pathway ISS