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death receptor 6

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1893

Nomenclature: death receptor 6

Abbreviated Name: DR6

Systematic Nomenclature: TNFRSF21

Family: Tumour necrosis factor (TNF) receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 655 6p12.3 TNFRSF21 TNF receptor superfamily member 21
Mouse 1 655 17 B3 Tnfrsf21 tumor necrosis factor receptor superfamily, member 21
Rat - - Tnfrsf21 TNF receptor superfamily member 21
Previous and Unofficial Names Click here for help
tumor necrosis factor receptor superfamily, member 21 | CD358 | tumor necrosis factor receptor superfamily
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
Adaptor proteins (Human)
Immunopharmacology Comments
Expressed predominantly in the thymus, spleen and white blood cells. May play a role in T helper cell activation, inflammation and immune regulation. Signals via the TRADD adaptor protein to the NF-κB and MAPK8/JNK pathways.
Immuno Process Associations
Immuno Process:  T cell (activation)
Immuno Process:  B cell (activation)
Immuno Process:  Immune regulation
Immuno Process:  Cytokine production & signalling
Immuno Process:  Chemotaxis & migration
Immuno Process:  Cellular signalling


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