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target has curated data in GtoImmuPdb
Target id: 1893
Nomenclature: death receptor 6
Abbreviated Name: DR6
Systematic Nomenclature: TNFRSF21
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 1 | 655 | 6p12.3 | TNFRSF21 | TNF receptor superfamily member 21 | |
| Mouse | 1 | 655 | 17 B3 | Tnfrsf21 | tumor necrosis factor receptor superfamily, member 21 | |
| Rat | - | - | Tnfrsf21 | TNF receptor superfamily member 21 | ||
| Previous and Unofficial Names |
| tumor necrosis factor receptor superfamily, member 21 | CD358 | tumor necrosis factor receptor superfamily |
| Database Links |
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| Alphafold | O75509 (Hs), Q9EPU5 (Mm) |
| Ensembl Gene | ENSG00000146072 (Hs), ENSMUSG00000023915 (Mm), ENSRNOG00000011517 (Rn) |
| Entrez Gene | 27242 (Hs), 94185 (Mm), 316256 (Rn) |
| Human Protein Atlas | ENSG00000146072 (Hs) |
| KEGG Gene | hsa:27242 (Hs), mmu:94185 (Mm), rno:316256 (Rn) |
| OMIM | 605732 (Hs) |
| Pharos | O75509 (Hs) |
| UniProtKB | O75509 (Hs), Q9EPU5 (Mm) |
| Wikipedia | TNFRSF21 (Hs) |
| Adaptor proteins (Human) |
| TRADD |
| Immunopharmacology Comments |
| Expressed predominantly in the thymus, spleen and white blood cells. May play a role in T helper cell activation, inflammation and immune regulation. Signals via the TRADD adaptor protein to the NF-κB and MAPK8/JNK pathways. |
| Immuno Process Associations | ||
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