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Tumour necrosis factor (TNF) receptor family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Dysregulated TNFR signalling is associated with many inflammatory disorders, including some forms of arthritis and inflammatory bowel disease, and targeting TNF has been an effective therapeutic strategy in these diseases and for cancer immunotherapy [1-2,5].

Receptors

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TNFR1 (tumor necrosis factor receptor 1 / TNFRSF1A) C Show summary » More detailed page go icon to follow link

TNFR2 (tumor necrosis factor receptor 2 / TNFRSF1B) C Show summary » More detailed page go icon to follow link

lymphotoxin β receptor / TNFRSF3 C Show summary » More detailed page go icon to follow link

OX40 / TNFRSF4 C Show summary » More detailed page go icon to follow link

CD40 / TNFRSF5 C Show summary » More detailed page go icon to follow link

Fas / TNFRSF6 C Show summary » More detailed page go icon to follow link

decoy receptor 3 / TNFRSF6B C Show summary » More detailed page go icon to follow link

CD27 / TNFRSF7 C Show summary » More detailed page go icon to follow link

CD30 / TNFRSF8 C Show summary » More detailed page go icon to follow link

4-1BB / TNFRSF9 C Show summary » More detailed page go icon to follow link

DR4 (death receptor 4 / TNFRSF10A) C Show summary »

DR5 (death receptor 5 / TNFRSF10B) C Show summary »

decoy receptor 1 / TNFRSF10C C Show summary »

decoy receptor 2 / TNFRSF10D C Show summary »

RANK (receptor activator of NF-kappa B / TNFRSF11A) C Show summary » More detailed page go icon to follow link

OPG (osteoprotegerin / TNFRSF11B) C Show summary » More detailed page go icon to follow link

DR3 (death receptor 3 / TNFRSF25) C Show summary » More detailed page go icon to follow link

TWEAK receptor / TNFRSF12A C Show summary » More detailed page go icon to follow link

TACI / TNFRSF13B C Show summary » More detailed page go icon to follow link

BAFF-R (BAFF receptor / TNFRSF13C) C Show summary » More detailed page go icon to follow link

HVEM (herpes virus entry mediator / TNFRSF14) C Show summary » More detailed page go icon to follow link

nerve growth factor receptor / TNFRSF16 C Show summary »

BCMA (B cell maturation antigen / TNFRSF17) C Show summary » More detailed page go icon to follow link

GITR (glucocorticoid-induced TNF receptor / TNFRSF18) C Show summary » More detailed page go icon to follow link

TAJ (toxicity and JNK inducer / TNFRSF19) C Show summary » More detailed page go icon to follow link

RELT / TNFRSF19L C Show summary » More detailed page go icon to follow link

DR6 (death receptor 6 / TNFRSF21) C Show summary » More detailed page go icon to follow link

TNFRSF22 C Show summary »

TNFRSF23 C Show summary »

ectodysplasin A2 isoform receptor / TNFRS27 C Show summary »

ectodysplasin 1, anhidrotic receptor C Show summary »

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Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Catalytic receptors. Br J Pharmacol. 176 Suppl 1: S247-S296.