GtoPdb Ligand ID: 5026

Synonyms: beta-nerve growth factor | beta-NGF | Oxervate® | Sentinel®
NGF is an approved drug (EMA (2017), FDA (2018))
Comment: Recombinant NGF (cenegermin, also known as cenegermin-bkbj) is used clinically as a peripherally selective agonist of TrkA and LNGFR. Note that the recombinant peptide is two amino acids shorter than the endogenous peptide, with the carboxy-terminal RA (Arg-Ala) removed.
Species: Human
Compound class Endogenous peptide in human, mouse or rat
Approved drug? Yes (EMA (2017), FDA (2018))
International Nonproprietary Names
INN number INN
10381 cenegermin
beta-nerve growth factor | beta-NGF | Oxervate® | Sentinel®
Gene symbol Gene name Species Precursor protein name Synonyms
NGF nerve growth factor Human prepro-beta-nerve growth factor nerve growth factor (beta polypeptide), NGFB
Database Links
Ensembl Gene ENSG00000134259 (Hs)
GtoPdb PubChem SID 178101723
Human Protein Atlas ENSG00000134259 (Hs)
Search PubMed clinical trials cenegermin
Search PubMed titles cenegermin
Search PubMed titles/abstracts cenegermin
UniProtKB P01138 (Hs)
Wikipedia Nerve_growth_factor