NGF   Click here for help

GtoPdb Ligand ID: 5026

Synonyms: beta-nerve growth factor | beta-NGF | Oxervate® | Sentinel®
Approved drug
NGF is an approved drug (EMA (2017), FDA (2018))
Comment: Recombinant NGF (cenegermin, also known as cenegermin-bkbj) is used clinically as a peripherally selective agonist of TrkA and LNGFR. Note that the recombinant peptide is two amino acids shorter than the endogenous peptide, with the carboxy-terminal RA (Arg-Ala) removed.
Species: Human
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Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Approved drug? Yes (EMA (2017), FDA (2018))
International Nonproprietary Names Click here for help
INN number INN
10381 cenegermin
Synonyms Click here for help
beta-nerve growth factor | beta-NGF | Oxervate® | Sentinel®
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
NGF nerve growth factor Human prepro-beta-nerve growth factor nerve growth factor (beta polypeptide), NGFB
Database Links Click here for help
Ensembl Gene ENSG00000134259 (Hs)
GtoPdb PubChem SID 178101723
Human Protein Atlas ENSG00000134259 (Hs)
Search PubMed clinical trials cenegermin
Search PubMed titles cenegermin
Search PubMed titles/abstracts cenegermin
UniProtKB P01138 (Hs)
Wikipedia Nerve_growth_factor