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target has curated data in GtoImmuPdb
Target id: 1870
Nomenclature: tumor necrosis factor receptor 1
Abbreviated Name: TNFR1
Systematic Nomenclature: TNFRSF1A
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 1 | 455 | 12p13.31 | TNFRSF1A | TNF receptor superfamily member 1A | |
| Mouse | 1 | 454 | 6 59.32 cM | Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a | |
| Rat | 1 | 461 | 4q42 | Tnfrsf1a | TNF receptor superfamily member 1A | |
| Previous and Unofficial Names |
| CD120a | p55TNFR | TNFAR | TNF-R1 | TNF-R55 | tumor necrosis factor receptor superfamily, member 1A | tumor necrosis factor receptor superfamily |
| Database Links |
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| Alphafold | P19438 (Hs), P25118 (Mm), P22934 (Rn) |
| ChEMBL Target | CHEMBL3378 (Hs) |
| Ensembl Gene | ENSG00000067182 (Hs), ENSMUSG00000030341 (Mm), ENSRNOG00000031312 (Rn) |
| Entrez Gene | 7132 (Hs), 21937 (Mm), 25625 (Rn) |
| Human Protein Atlas | ENSG00000067182 (Hs) |
| KEGG Gene | hsa:7132 (Hs), mmu:21937 (Mm), rno:25625 (Rn) |
| OMIM | 191190 (Hs) |
| Pharos | P19438 (Hs) |
| UniProtKB | P19438 (Hs), P25118 (Mm), P22934 (Rn) |
| Wikipedia | TNFRSF1A (Hs) |
| Natural/Endogenous Ligands |
| lymphotoxin-α {Sp: Human} |
| tumour necrosis factor membrane form {Sp: Human} |
| tumour necrosis factor shed form {Sp: Human} |
| Adaptor proteins (Human) |
| TRADD |
| Other Binding Ligands | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Immunopharmacology Comments |
| We have included TNFR1 in GtoImmuPdb based on it being a receptor for lymphotoxin-α, a cytotoxic protein performing a variety of important roles in immune system development and regulation [1-2]. |
| Immuno Process Associations | ||
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1. Gubernatorova EO, Tumanov AV. (2016) Tumor Necrosis Factor and Lymphotoxin in Regulation of Intestinal Inflammation. Biochemistry Mosc, 81 (11): 1309-1325. [PMID:27914457]
2. Ngo VN, Korner H, Gunn MD, Schmidt KN, Riminton DS, Cooper MD, Browning JL, Sedgwick JD, Cyster JG. (1999) Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. J Exp Med, 189 (2): 403-12. [PMID:9892622]
