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Synonyms: DB36 
Compound class: Synthetic organic
Comment: Compound 1 inhibits the co-stimulatory protein-protein interaction between the tumour necrosis factor receptor OX40 and the endogenous OX-40 ligand, by binding to the receptor rather than the ligand . This interaction is a promising therapeutic target for immunomodulation. Cellular assays indicate that compound 1 has partial agonist activity at OX40.
PubChem CID 6817797 respresents an alternative stereochemical structure for this compound.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Compound class||Synthetic organic|
|GtoPdb PubChem SID||315661177|
|Search Google for chemical match using the InChIKey||ADRMADAIKSWNOR-GOCYIQQKSA-N|
|Search Google for chemicals with the same backbone||ADRMADAIKSWNOR|
|UniChem Compound Search for chemical match using the InChIKey||ADRMADAIKSWNOR-GOCYIQQKSA-N|
|UniChem Connectivity Search for chemical match using the InChIKey||ADRMADAIKSWNOR-GOCYIQQKSA-N|