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Target not currently curated in GtoImmuPdb
Target id: 1891
Nomenclature: toxicity and JNK inducer
Abbreviated Name: TAJ
Systematic Nomenclature: TNFRSF19
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 1 | 423 | 13q12.12 | TNFRSF19 | TNF receptor superfamily member 19 | |
| Mouse | 1 | 416 | 14 D1 | Tnfrsf19 | tumor necrosis factor receptor superfamily, member 19 | |
| Rat | - | - | Tnfrsf19 | TNF receptor superfamily member 19 | ||
| Previous and Unofficial Names |
| TRADE | TROY | tumor necrosis factor receptor superfamily, member 19 | TAJ-alpha | tumor necrosis factor receptor superfamily member 19 | tumor necrosis factor receptor superfamily |
| Database Links |
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| Alphafold | Q9NS68 (Hs), Q9JLL3 (Mm) |
| Ensembl Gene | ENSG00000127863 (Hs), ENSMUSG00000060548 (Mm), ENSRNOG00000014265 (Rn) |
| Entrez Gene | 55504 (Hs), 29820 (Mm), 290300 (Rn) |
| Human Protein Atlas | ENSG00000127863 (Hs) |
| KEGG Gene | hsa:55504 (Hs), mmu:29820 (Mm), rno:290300 (Rn) |
| OMIM | 606122 (Hs) |
| Pharos | Q9NS68 (Hs) |
| UniProtKB | Q9NS68 (Hs), Q9JLL3 (Mm) |
| Wikipedia | TNFRSF19 (Hs) |
| Natural/Endogenous Ligands |
| lymphotoxin-α {Sp: Human} |
| Adaptor proteins (Human) |
| TRAF1, TRAF2, TRAF3, TRAF5 |
| Other Binding Ligands | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Immuno Process Associations | ||
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| General Comments |
| TNFRSF19 protein, also known as JAC or TROY, has been implicated in the migratory potential of microglial cells in glioblastoma multiforme (GBM) [2]. Propentofylline (PubChem CID 4938), a compound with central nervous system glial modulating, neuroprotective and anti-inflammatory actions reduces rodent model GBM growth in a JAC-dependent manner [1,3]. |
1. Dhruv HD, Roos A, Tomboc PJ, Tuncali S, Chavez A, Mathews I, Berens ME, Loftus JC, Tran NL. (2016) Propentofylline inhibits glioblastoma cell invasion and survival by targeting the TROY signaling pathway. J Neurooncol, 126 (3): 397-404. [PMID:26559543]
2. Jacobs VL, Landry RP, Liu Y, Romero-Sandoval EA, De Leo JA. (2012) Propentofylline decreases tumor growth in a rodent model of glioblastoma multiforme by a direct mechanism on microglia. Neuro-oncology, 14 (2): 119-31. [PMID:22086978]
3. Jacobs VL, Liu Y, De Leo JA. (2012) Propentofylline targets TROY, a novel microglial signaling pathway. PLoS ONE, 7 (5): e37955. [PMID:22649568]
