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target has curated data in GtoImmuPdb
Target id: 1882
Nomenclature: osteoprotegerin
Abbreviated Name: OPG
Systematic Nomenclature: TNFRSF11B
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | 401 | 8q24.12 | TNFRSF11B | TNF receptor superfamily member 11b | |
| Mouse | - | 401 | 15 D1 | Tnfrsf11b | tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) | |
| Rat | - | 401 | 7q32 | Tnfrsf11b | TNF receptor superfamily member 11B | |
| Previous and Unofficial Names |
| osteoclastogenesis inhibitory factor | TR1 | tumor necrosis factor receptor superfamily, member 11b | tumor necrosis factor receptor superfamily member 11b | tumor necrosis factor receptor superfamily |
| Database Links |
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| Alphafold | O00300 (Hs), O08712 (Mm), O08727 (Rn) |
| Ensembl Gene | ENSG00000164761 (Hs), ENSMUSG00000063727 (Mm), ENSRNOG00000008336 (Rn) |
| Entrez Gene | 4982 (Hs), 18383 (Mm), 25341 (Rn) |
| Human Protein Atlas | ENSG00000164761 (Hs) |
| KEGG Gene | hsa:4982 (Hs), mmu:18383 (Mm), rno:25341 (Rn) |
| OMIM | 602643 (Hs) |
| Pharos | O00300 (Hs) |
| UniProtKB | O00300 (Hs), O08712 (Mm), O08727 (Rn) |
| Wikipedia | TNFRSF11B (Hs) |
| Immunopharmacology Comments |
| The protein product of the TNFRSF11B gene, osteoprotegerin, acts as a soluble decoy receptor for RANK ligand (RANKL) and for TRAIL. Experimental evidence links the RANK/RANKL signalling pathway with the inflammatory activation of microglial cells relevant in the development of infection-induced perinatal brain injury [1], and as an inhibitory factor in the inflammation underlying coronary artery atherosclerotic plaque formation [2]. |
| Immuno Process Associations | ||
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1. Kichev A, Eede P, Gressens P, Thornton C, Hagberg H. (2017) Implicating Receptor Activator of NF-κB (RANK)/RANK Ligand Signalling in Microglial Responses to Toll-Like Receptor Stimuli. Dev Neurosci, 39 (1-4): 192-206. [PMID:28402971]
2. Ozkok A, Caliskan Y, Sakaci T, Erten G, Karahan G, Ozel A, Unsal A, Yildiz A. (2012) Osteoprotegerin/RANKL axis and progression of coronary artery calcification in hemodialysis patients. Clin J Am Soc Nephrol, 7 (6): 965-73. [PMID:22490874]
