Quaternary Structure: Complexes

Interleukin-3 receptor

Interleukin-5 receptor

Granulocyte macrophage colony-stimulating factor receptor

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	897	22q12.3	CSF2RB	colony stimulating factor 2 receptor subunit beta
Mouse	1	896	15 37.36 cM	Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
Rat	-	-	7q34	Csf2rb	colony stimulating factor 2 receptor subunit beta

Previous and Unofficial Names

CD131 | GM-CSF/IL-3/IL-5 receptor common beta subunit | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | colony stimulating factor 2 receptor | colony stimulating factor 2 receptor beta common subunit

Database Links
Alphafold	P32927 (Hs), P26955 (Mm)
CATH/Gene3D	2.60.40.10
ChEMBL Target	CHEMBL4804252 (Hs), CHEMBL2364169 (Hs)
DrugBank Target	P32927 (Hs)
Ensembl Gene	ENSG00000100368 (Hs), ENSMUSG00000071713 (Mm), ENSRNOG00000000187 (Rn)
Human Protein Atlas	ENSG00000100368 (Hs)
Pharos	P32927 (Hs)
UniProtKB	P32927 (Hs), P26955 (Mm)
Wikipedia	CSF2RB (Hs)

Immunopharmacology Comments

This a signal transducing protein subunit shared by the functional receptor heterodimers for the cytokines IL-3, IL-5 and GM-CSF, with each receptor having a unique ligand binding alpha subunit.

Immuno Process Associations

Immuno Process:  Cytokine production & signalling