Top ▲
GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.
| Quaternary Structure: Complexes |
| Interleukin-3 receptor |
| Interleukin-5 receptor |
| Granulocyte macrophage colony-stimulating factor receptor |
Gene and Protein Information  |
||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 1 | 897 | 22q12.3 | CSF2RB | colony stimulating factor 2 receptor subunit beta | |
| Mouse | 1 | 896 | 15 37.36 cM | Csf2rb | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | |
| Rat | - | - | 7q34 | Csf2rb | colony stimulating factor 2 receptor subunit beta | |
| Previous and Unofficial Names |
| CD131 | GM-CSF/IL-3/IL-5 receptor common beta subunit | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | colony stimulating factor 2 receptor | colony stimulating factor 2 receptor beta common subunit |
| Database Links |
|
| Alphafold | P32927 (Hs), P26955 (Mm) |
| CATH/Gene3D | 2.60.40.10 |
| ChEMBL Target | CHEMBL4804252 (Hs), CHEMBL2364169 (Hs) |
| DrugBank Target | P32927 (Hs) |
| Ensembl Gene | ENSG00000100368 (Hs), ENSMUSG00000071713 (Mm), ENSRNOG00000000187 (Rn) |
| Human Protein Atlas | ENSG00000100368 (Hs) |
| Pharos | P32927 (Hs) |
| UniProtKB | P32927 (Hs), P26955 (Mm) |
| Wikipedia | CSF2RB (Hs) |
| Immunopharmacology Comments |
| This a signal transducing protein subunit shared by the functional receptor heterodimers for the cytokines IL-3, IL-5 and GM-CSF, with each receptor having a unique ligand binding alpha subunit. |
IL-3 receptor family: Cytokine receptor common β subunit. Last modified on 22/03/2017. Accessed on 03/11/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2306.
target has curated data in GtoImmuPdb
