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target has curated data in GtoImmuPdb
Target id: 1734
Nomenclature: Interleukin 1 receptor, type I
| Quaternary Structure: Complexes |
| Interleukin-1 receptor, type I |
Gene and Protein Information  |
||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 1 | 569 | 2q11.2-q12.1 | IL1R1 | interleukin 1 receptor type 1 | |
| Mouse | 1 | 576 | 1 18.81 cM | Il1r1 | interleukin 1 receptor, type I | |
| Rat | 1 | 576 | 9q22 | Il1r1 | interleukin 1 receptor type 1 | |
| Previous and Unofficial Names |
| CD121A | IL1RA | CD121 antigen-like family member A | IL-1R-alpha | interleukin 1 beta receptor type 1 short transmembrane form | interleukin 1 beta receptor type 1 soluble form | interleukin 1 bete receptor type 1 long transmembrane form | interleukin-1 receptor alpha | interleukin 1 receptor |
| Database Links |
|
| Alphafold | P14778 (Hs), P13504 (Mm), Q02955 (Rn) |
| CATH/Gene3D | 3.40.50.10140, 2.60.40.10 |
| ChEMBL Target | CHEMBL1959 (Hs), CHEMBL2189148 (Mm) |
| DrugBank Target | P14778 (Hs) |
| Ensembl Gene | ENSG00000115594 (Hs), ENSMUSG00000026072 (Mm), ENSRNOG00000014504 (Rn) |
| Entrez Gene | 3554 (Hs), 16177 (Mm), 25663 (Rn) |
| Human Protein Atlas | ENSG00000115594 (Hs) |
| KEGG Gene | hsa:3554 (Hs), mmu:16177 (Mm), rno:25663 (Rn) |
| OMIM | 147810 (Hs) |
| Pharos | P14778 (Hs) |
| UniProtKB | P14778 (Hs), P13504 (Mm), Q02955 (Rn) |
| Wikipedia | IL1R1 (Hs) |
| Immunopharmacology Comments |
| This is one of the subunits of the functional IL-1 receptor type I heterodimer. |
Immunoglobulin-like family of IL-1 receptors: Interleukin 1 receptor, type I. Last modified on 22/03/2017. Accessed on 31/10/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1734.
