Interleukin-15 receptor subunit α | IL-2 receptor family | IUPHAR/BPS Guide to PHARMACOLOGY

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Interleukin-15 receptor subunit α

target has curated data in GtoImmuPdb

Target id: 1702

Nomenclature: Interleukin-15 receptor subunit α

Family: IL-2 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Quaternary Structure: Complexes
Interleukin-15 receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 267 10p15.1 IL15RA interleukin 15 receptor subunit alpha
Mouse 1 263 Il15ra interleukin 15 receptor, alpha chain
Rat - - Il15ra interleukin 15 receptor subunit alpha
Previous and Unofficial Names
CD215 | interleukin 15 receptor, alpha | interleukin 15 receptor
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas

Download all structure-activity data for this target as a CSV file

Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
IL-15 {Sp: Human} Hs Agonist 11.4 pKd 1
pKd 11.4 (Kd 3.8x10-12 M) [1]
Description: Binding of recombinant hIL-15 to IL-15Rα subunit using Surface Plasmon Resonance (SPR)
Immunopharmacology Comments
This is the ligand binding subunit of the functional IL-15 receptor complex.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 3 GO processes
GO:0004896 cytokine receptor activity TAS
GO:0035723 interleukin-15-mediated signaling pathway IMP
GO:0042010 interleukin-15 receptor activity IDA
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0050766 positive regulation of phagocytosis IMP


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1. Liu X, Kirk PB, Chang T, Charych DH. (2017) Conjugates of an il-15 moiety and a polymer. Patent number: US20170035898. Assignee: Nektar Therapeutics. Priority date: 03/04/2014. Publication date: 09/02/2017.

How to cite this page

IL-2 receptor family: Interleukin-15 receptor subunit α. Last modified on 31/07/2017. Accessed on 14/11/2019. IUPHAR/BPS Guide to PHARMACOLOGY,