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Interleukin-15 receptor

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2302

Nomenclature: Interleukin-15 receptor

Family: IL-2 receptor family

Quaternary Structure: Subunits
Interleukin-2 receptor subunit β (Ligand-binding subunit)
Interleukin-15 receptor subunit α (Ligand-binding subunit)
Interleukin-2 receptor subunit γ (Other subunit)
Natural/Endogenous Ligands Click here for help
IL-15 {Sp: Human}

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Agonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ALT-803 Peptide Immunopharmacology Ligand Hs Agonist 10.8 pEC50 2
pEC50 10.8 (EC50 1.56x10-11 M) [2]
Description: Evaluated using an IL-15 dependent 32Dβ cell proliferation assay.
ALT-803 Peptide Immunopharmacology Ligand Hs Agonist ~12.3 pIC50 3
pIC50 ~12.3 (IC50 ~5x10-13 M) [3]
Description: Binding of rhIL-15N72D to hIL-15R in vitro.
IL-15 {Sp: Human} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist 11.4 pIC50 3
pIC50 11.4 (IC50 3.8x10-12 M) [3]
Description: Binding of rhIL-15 in vitro, using cells expressing the intact hIL-15Rα-hIL-15Rβ-hγ complex.
Immunopharmacology Comments
The functional IL-15 receptor is a heteromer consisting of the high affinity ligand binding interleukin-15 receptor subunit α (IL15RA) and common IL-2-γ and -β signal transducing subunits (IL2RG and IL2RB) [1].

References

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1. Anderson DM, Kumaki S, Ahdieh M, Bertles J, Tometsko M, Loomis A, Giri J, Copeland NG, Gilbert DJ, Jenkins NA et al.. (1995) Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes. J Biol Chem, 270 (50): 29862-9. [PMID:8530383]

2. Han KP, Zhu X, Liu B, Jeng E, Kong L, Yovandich JL, Vyas VV, Marcus WD, Chavaillaz PA, Romero CA et al.. (2011) IL-15:IL-15 receptor alpha superagonist complex: high-level co-expression in recombinant mammalian cells, purification and characterization. Cytokine, 56 (3): 804-10. [PMID:22019703]

3. Zhu X, Marcus WD, Xu W, Lee HI, Han K, Egan JO, Yovandich JL, Rhode PR, Wong HC. (2009) Novel human interleukin-15 agonists. J Immunol, 183 (6): 3598-607. [PMID:19710453]

How to cite this page

IL-2 receptor family: Interleukin-15 receptor. Last modified on 06/07/2021. Accessed on 19/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2302.