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nucleotide binding oligomerization domain containing 2

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1763

Nomenclature: nucleotide binding oligomerization domain containing 2

Abbreviated Name: NOD2

Family: NOD-like receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1040 16q12.1 NOD2 nucleotide binding oligomerization domain containing 2
Mouse - 1020 8 C3 Nod2 nucleotide-binding oligomerization domain containing 2
Rat - - 19p11 Nod2 nucleotide-binding oligomerization domain containing 2
Previous and Unofficial Names Click here for help
BLAU | CARD15 | CLR16.3 | IBD1 | PSORAS1 | caspase recruitment domain family, member 15 | NLR family, CARD domain containing 2 | NOD-like receptor C2 | NLRC2 | ACUG | NOD2B | CD | nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2 (NLRC2) | nucleotide-binding oligomerization domain containing 2
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ML130 Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition <4.7 pIC50 1
pIC50 <4.7 (IC50 >2x10-5 M) [1]
Immunopharmacology Comments
NOD2 is an intracellular pattern recognition receptor that initiates an immune response to bacterial molecules containing muramyl dipeptide (MDP).

Mutations in NOD proteins are implicated in various inflammatory diseases associated with aberrant NF-κB activity; NF-κB being a major component of the signaling pathways involved in apoptosis, inflammation, and the immune response.
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Antigen presentation
Immuno Process:  T cell (activation)
Immuno Process:  B cell (activation)
Immuno Process:  Immune regulation
Immuno Process:  Cytokine production & signalling
Immuno Process:  Chemotaxis & migration
Immuno Process:  Cellular signalling
Physiological Functions Comments
Pro-inflammatory, involved in autophagy.
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Behcet syndrome
Synonyms: Behçet disease [Orphanet: ORPHA117]
Behcet's disease [Disease Ontology: DOID:13241]
Disease Ontology: DOID:13241
OMIM: 109650
Orphanet: ORPHA117
Disease:  Blau syndrome; BLAUS
Disease Ontology: DOID:0050678
OMIM: 186580
Orphanet: ORPHA90340
Disease:  Crohn's disease
Synonyms: Crohn disease [Disease Ontology: DOID:8778]
Inflammatory bowel disease 1; IBD1 [OMIM: 266600]
Disease Ontology: DOID:8778
OMIM: 266600
Orphanet: ORPHA206
Disease:  Sarcoidosis, early-onset
Disease Ontology: DOID:11335
OMIM: 609464
Disease:  Ulcerative colitis
Synonyms: Inflammatory bowel disease 1; IBD1 [OMIM: 266600]
Disease Ontology: DOID:8577
OMIM: 266600
Orphanet: ORPHA771


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1. Khan PM, Correa RG, Divlianska DB, Peddibhotla S, Sessions EH, Magnuson G, Brown B, Suyama E, Yuan H, Mangravita-Novo A et al.. (2011) Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation. ACS Med Chem Lett, 2 (10): 780-785. [PMID:22003428]


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