Interleukin 10 receptor, α subunit | IL-10 receptor family | IUPHAR/BPS Guide to PHARMACOLOGY

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Interleukin 10 receptor, α subunit

target has curated data in GtoImmuPdb

Target id: 1727

Nomenclature: Interleukin 10 receptor, α subunit

Family: IL-10 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Quaternary Structure: Complexes
Interleukin-10 receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 578 11q23.3 IL10RA interleukin 10 receptor subunit alpha
Mouse 1 575 Il10ra interleukin 10 receptor, alpha
Rat - - Il10ra interleukin 10 receptor subunit alpha
Previous and Unofficial Names
interleukin 10 receptor | CD210 | Interleukin-10 α | interleukin 10 receptor, alpha
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
IL-10 {Sp: Human} Hs Agonist 9.7 – 10.3 pEC50 1
pEC50 9.7 – 10.3 (EC50 2x10-10 – 5x10-11 M) [1]
Immunopharmacology Comments
Interleukin 10 receptor, α subunit is a component of the functional IL-10 receptor heterodimer.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 3 GO processes
GO:0004896 cytokine receptor activity IBA
GO:0004920 interleukin-10 receptor activity IBA
GO:0019221 cytokine-mediated signaling pathway IBA
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes
GO:0070086 ubiquitin-dependent endocytosis IDA

References

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1. Mosser DM, Zhang X. (2008) Interleukin-10: new perspectives on an old cytokine. Immunol. Rev., 226: 205-18. [PMID:19161426]

How to cite this page

IL-10 receptor family: Interleukin 10 receptor, α subunit. Last modified on 11/04/2017. Accessed on 22/10/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1727.