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Interleukin 10 receptor, α subunit

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1727

Nomenclature: Interleukin 10 receptor, α subunit

Family: IL-10 receptor family

Quaternary Structure: Complexes
Interleukin-10 receptor
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 578 11q23.3 IL10RA interleukin 10 receptor subunit alpha
Mouse 1 575 9 24.84 cM Il10ra interleukin 10 receptor, alpha
Rat - - Il10ra interleukin 10 receptor subunit alpha
Previous and Unofficial Names Click here for help
interleukin 10 receptor | CD210 | Interleukin-10 α | interleukin 10 receptor, alpha
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas

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Ligand Sp. Action Value Parameter Reference
IL-10 {Sp: Human} Peptide Click here for species-specific activity table Immunopharmacology Ligand Hs Agonist 9.7 – 10.3 pEC50 1
pEC50 9.7 – 10.3 (EC50 2x10-10 – 5x10-11 M) [1]
Immunopharmacology Comments
Interleukin 10 receptor, α subunit is a component of the functional IL-10 receptor heterodimer.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 3 GO processes
GO:0004896 cytokine receptor activity IBA
GO:0004920 interleukin-10 receptor activity IBA
GO:0019221 cytokine-mediated signaling pathway IBA
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes
GO:0070086 ubiquitin-dependent endocytosis IDA


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1. Mosser DM, Zhang X. (2008) Interleukin-10: new perspectives on an old cytokine. Immunol Rev, 226: 205-18. [PMID:19161426]

How to cite this page

IL-10 receptor family: Interleukin 10 receptor, α subunit. Last modified on 11/04/2017. Accessed on 29/05/2023. IUPHAR/BPS Guide to PHARMACOLOGY,