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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1882

Nomenclature: osteoprotegerin

Abbreviated Name: OPG

Systematic Nomenclature: TNFRSF11B

Family: Tumour necrosis factor (TNF) receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 401 8q24.12 TNFRSF11B TNF receptor superfamily member 11b
Mouse - 401 15 D1 Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
Rat - 401 7q32 Tnfrsf11b TNF receptor superfamily member 11B
Previous and Unofficial Names Click here for help
osteoclastogenesis inhibitory factor | TR1 | tumor necrosis factor receptor superfamily, member 11b | tumor necrosis factor receptor superfamily member 11b | tumor necrosis factor receptor superfamily
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
Immunopharmacology Comments
The protein product of the TNFRSF11B gene, osteoprotegerin, acts as a soluble decoy receptor for RANK ligand (RANKL) and for TRAIL. Experimental evidence links the RANK/RANKL signalling pathway with the inflammatory activation of microglial cells relevant in the development of infection-induced perinatal brain injury [1], and as an inhibitory factor in the inflammation underlying coronary artery atherosclerotic plaque formation [2].
Immuno Process Associations
Immuno Process:  Cytokine production & signalling


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1. Kichev A, Eede P, Gressens P, Thornton C, Hagberg H. (2017) Implicating Receptor Activator of NF-κB (RANK)/RANK Ligand Signalling in Microglial Responses to Toll-Like Receptor Stimuli. Dev Neurosci, 39 (1-4): 192-206. [PMID:28402971]

2. Ozkok A, Caliskan Y, Sakaci T, Erten G, Karahan G, Ozel A, Unsal A, Yildiz A. (2012) Osteoprotegerin/RANKL axis and progression of coronary artery calcification in hemodialysis patients. Clin J Am Soc Nephrol, 7 (6): 965-73. [PMID:22490874]


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