osteoprotegerin | Tumour necrosis factor (TNF) receptor family | IUPHAR/BPS Guide to PHARMACOLOGY

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osteoprotegerin

target has curated data in GtoImmuPdb

Target id: 1882

Nomenclature: osteoprotegerin

Abbreviated Name: OPG

Systematic Nomenclature: TNFRSF11B

Family: Tumour necrosis factor (TNF) receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - TNFRSF11B TNF receptor superfamily member 11b
Mouse - - Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
Rat - - Tnfrsf11b TNF receptor superfamily member 11B
Previous and Unofficial Names
osteoclastogenesis inhibitory factor | TR1 | tumor necrosis factor receptor superfamily, member 11b | tumor necrosis factor receptor superfamily member 11b | tumor necrosis factor receptor superfamily
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Immunopharmacology Comments
The protein product of the TNFRSF11B gene, osteoprotegerin, acts as a soluble decoy receptor for RANK ligand (RANKL) and for TRAIL. Experimental evidence links the RANK/RANKL signalling pathway with the inflammatory activation of microglial cells relevant in the development of infection-induced perinatal brain injury [1], and as an inhibitory factor in the inflammation underlying coronary artery atherosclerotic plaque formation [2].
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0033209 tumor necrosis factor-mediated signaling pathway TAS

References

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1. Kichev A, Eede P, Gressens P, Thornton C, Hagberg H. (2017) Implicating Receptor Activator of NF-κB (RANK)/RANK Ligand Signalling in Microglial Responses to Toll-Like Receptor Stimuli. Dev. Neurosci., 39 (1-4): 192-206. [PMID:28402971]

2. Ozkok A, Caliskan Y, Sakaci T, Erten G, Karahan G, Ozel A, Unsal A, Yildiz A. (2012) Osteoprotegerin/RANKL axis and progression of coronary artery calcification in hemodialysis patients. Clin J Am Soc Nephrol, 7 (6): 965-73. [PMID:22490874]

Contributors

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