TLR5 | Toll-like receptor family | IUPHAR/BPS Guide to PHARMACOLOGY

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TLR5

target has curated data in GtoImmuPdb

Target id: 1755

Nomenclature: TLR5

Family: Toll-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 838 1q32.3-q42 TLR5 toll like receptor 5
Mouse - 833 1 86.12 cM Tlr5 toll-like receptor 5
Rat - - 13q26 Tlr5 toll-like receptor 5
Previous and Unofficial Names
SLEB1 | TIL3 | Toll/interleukin-1 receptor-like protein 3 | toll-like receptor 5 | MELIOS | RP11-239E10.1
Database Links
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Immunopharmacology Comments
TLR5 induces a pro-inflammatory response upon detection of extracellular bacterial flagellin from invading mobile bacteria [1]. In contrast, cytosolic flagellin in macrophages is recognised by NOD-like receptor NLRC4 (Ipaf).
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 5 GO processes
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS
GO:0034123 positive regulation of toll-like receptor signaling pathway IDA
GO:0034146 toll-like receptor 5 signaling pathway TAS
click arrow to show/hide IEA associations
GO:0006954 inflammatory response IEA
GO:0045087 innate immune response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS
GO:0034123 positive regulation of toll-like receptor signaling pathway IDA
GO:0034146 toll-like receptor 5 signaling pathway TAS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 2 GO processes
GO:0032757 positive regulation of interleukin-8 production IDA
click arrow to show/hide IEA associations
GO:0050707 regulation of cytokine secretion IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 3 GO processes
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS
GO:0034123 positive regulation of toll-like receptor signaling pathway IDA
GO:0034146 toll-like receptor 5 signaling pathway TAS
Clinically-Relevant Mutations and Pathophysiology
Disease:  Asthma, susceptibility to
Disease Ontology: DOID:2841
OMIM: 600807
Disease:  Gastric cancer
Synonyms: Stomach cancer
Disease Ontology: DOID:10534
OMIM: 613659
Disease:  Legionnaire disease, susceptibility to
Synonyms: Legionnaires' disease [Disease Ontology: DOID:10457]
Disease Ontology: DOID:10457
OMIM: 608556
Disease:  Melioidosis, susceptibility to
Disease Ontology: DOID:5052
OMIM: 615557
Disease:  Metabolic syndrome
Synonyms: Metabolic syndrome X [Disease Ontology: DOID:14221]
Disease Ontology: DOID:14221
Disease:  Pneumonia
Disease Ontology: DOID:552
Disease:  Systemic lupus erythematosus, susceptibility to, 1; SLEB1
Synonyms: Systemic lupus erythematosus [Disease Ontology: DOID:9074]
Disease Ontology: DOID:9074
OMIM: 601744

References

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1. Miao EA, Andersen-Nissen E, Warren SE, Aderem A. (2007) TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system. Semin Immunopathol, 29 (3): 275-88. [PMID:17690885]

Contributors

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How to cite this page

Clare Bryant, Tom P. Monie.
Toll-like receptor family: TLR5. Last modified on 15/03/2017. Accessed on 18/09/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1755.