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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1755

Nomenclature: TLR5

Family: Toll-like receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 858 1q41 TLR5 toll like receptor 5
Mouse 1 859 1 86.12 cM Tlr5 toll-like receptor 5
Rat - - 13q26 Tlr5 toll-like receptor 5
Previous and Unofficial Names Click here for help
SLEB1 | TIL3 | Toll/interleukin-1 receptor-like protein 3 | toll-like receptor 5 | MELIOS | RP11-239E10.1
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
Immunopharmacology Comments
TLR5 induces a pro-inflammatory response upon detection of extracellular bacterial flagellin from invading mobile bacteria [1]. In contrast, cytosolic flagellin in macrophages is recognised by NOD-like receptor NLRC4 (Ipaf).
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Immune regulation
Immuno Process:  Cytokine production & signalling
Immuno Process:  Cellular signalling
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Asthma, susceptibility to
Disease Ontology: DOID:2841
OMIM: 600807
Disease:  Gastric cancer
Synonyms: Stomach cancer
Disease Ontology: DOID:10534
OMIM: 613659
Disease:  Legionnaire disease, susceptibility to
Synonyms: Legionnaires' disease [Disease Ontology: DOID:10457]
Disease Ontology: DOID:10457
OMIM: 608556
Disease:  Melioidosis, susceptibility to
Disease Ontology: DOID:5052
OMIM: 615557
Disease:  Metabolic syndrome
Synonyms: Metabolic syndrome X [Disease Ontology: DOID:14221]
Disease Ontology: DOID:14221
Disease:  Pneumonia
Disease Ontology: DOID:552
Disease:  Systemic lupus erythematosus, susceptibility to, 1; SLEB1
Synonyms: Systemic lupus erythematosus [Disease Ontology: DOID:9074]
Disease Ontology: DOID:9074
OMIM: 601744


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1. Miao EA, Andersen-Nissen E, Warren SE, Aderem A. (2007) TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system. Semin Immunopathol, 29 (3): 275-88. [PMID:17690885]


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