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Toll-like receptor family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Members of the toll-like family of receptors (nomenclature recommended by the NC-IUPHAR subcommittee on pattern recognition receptors, [2]) share significant homology with the interleukin-1 receptor family and appear to require dimerization either as homo- or heterodimers for functional activity. Heterodimerization appears to influence the potency of ligand binding substantially (e.g. TLR1/2 and TLR2/6, [19-20]). TLR1, TLR2, TLR4, TLR5, TLR6 and TLR11 are cell-surface proteins, while other members are associated with intracellular organelles, signalling through the MyD88-dependent pathways (with the exception of TLR3). As well as responding to exogenous infectious agents [3], it has been suggested that selected members of the family may be activated by endogenous ligands, such as hsp60 (HSPD1, P10809) [15].

Receptors

TLR1 C Show summary » More detailed page

TLR2 C Show summary » More detailed page

TLR3 C Show summary » More detailed page

TLR4 C Show summary » More detailed page

TLR5 C Show summary » More detailed page

TLR6 C Show summary » More detailed page

TLR7 C Show summary » More detailed page

TLR8 C Show summary » More detailed page

TLR9 C Show summary » More detailed page

TLR10 C Show summary » More detailed page

TLR11 C Show summary » More detailed page

Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Catalytic receptors. Br J Pharmacol. 176 Suppl 1: S247-S296.