Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	796	4p14	TLR6	toll like receptor 6
Mouse	1	795	5 33.54 cM	Tlr6	toll-like receptor 6
Rat	-	-	14p11	Tlr6	toll-like receptor 6

Previous and Unofficial Names

CD286 | toll-like receptor 6

Database Links
Alphafold	Q9Y2C9 (Hs), Q9EPW9 (Mm)
CATH/Gene3D	3.40.50.10140, 3.80.10.10
ChEMBL Target	CHEMBL3259477 (Hs), CHEMBL2146341 (Mm)
Ensembl Gene	ENSG00000174130 (Hs), ENSMUSG00000051498 (Mm), ENSRNOG00000002161 (Rn)
Entrez Gene	10333 (Hs), 21899 (Mm), 305353 (Rn)
Human Protein Atlas	ENSG00000174130 (Hs)
KEGG Gene	hsa:10333 (Hs), mmu:21899 (Mm), rno:305353 (Rn)
OMIM	605403 (Hs)
Pharos	Q9Y2C9 (Hs)
UniProtKB	Q9Y2C9 (Hs), Q9EPW9 (Mm)
Wikipedia	TLR6 (Hs)

Immunopharmacology Comments

TLR6 forms heterodimers with TLR2 to detect a wide range of bacterial lipopeptides (LP) from bacterial cell membranes, and effect an immune response [1]. TLR2/6 dimers perferentially detect diacylated LP [2]. Pam2Cys-SKKKK is a synthetic LP which induces signalling through TLR2/TLR6 heteromers. Activation of TLR2-TLR6 heteromers by LP promotes formation of a functional signalling complex that includes MyD88 and IL-1R-associated kinase (IRAK) proteins, that ultimately initiates NF-κB-mediated cytokine production.

Cell Type Associations

Immuno Cell Type:  Dendritic cells Cell Ontology Term:   dendritic cell (CL:0000451) Comment:  NB monocyte-derived immature DCs. References:  2

Immuno Cell Type:  Granulocytes Cell Ontology Term:   neutrophil (CL:0000775) References:  2

Immuno Cell Type:  Macrophages & monocytes Cell Ontology Term:   monocyte (CL:0000576) References:  2

Immuno Process Associations

Immuno Process:  Cellular signalling GO Annotations:  Associated to 8 GO processes GO:0002224 toll-like receptor signaling pathway IBA GO:0002755 MyD88-dependent toll-like receptor signaling pathway IDA GO:0034136 negative regulation of toll-like receptor 2 signaling pathway IGI GO:0035666 TRIF-dependent toll-like receptor signaling pathway ISS GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway IDA GO:0043032 positive regulation of macrophage activation ISS GO:1900227 positive regulation of NLRP3 inflammasome complex assembly ISS click arrow to show/hide IEA associations GO:0001774 microglial cell activation IEA

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 5 GO processes GO:0032717 negative regulation of interleukin-8 production IGI GO:0032731 positive regulation of interleukin-1 beta production ISS GO:0032755 positive regulation of interleukin-6 production ISS GO:1900017 positive regulation of cytokine production involved in inflammatory response ISS GO:1900227 positive regulation of NLRP3 inflammasome complex assembly ISS

Immuno Process:  Immune regulation GO Annotations:  Associated to 8 GO processes GO:0002224 toll-like receptor signaling pathway IBA GO:0002755 MyD88-dependent toll-like receptor signaling pathway IDA GO:0034136 negative regulation of toll-like receptor 2 signaling pathway IGI GO:0035666 TRIF-dependent toll-like receptor signaling pathway ISS GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway IDA GO:0043032 positive regulation of macrophage activation ISS GO:1900017 positive regulation of cytokine production involved in inflammatory response ISS GO:1900227 positive regulation of NLRP3 inflammasome complex assembly ISS

Immuno Process:  Inflammation GO Annotations:  Associated to 11 GO processes GO:0002224 toll-like receptor signaling pathway IBA GO:0002755 MyD88-dependent toll-like receptor signaling pathway IDA GO:0006954 inflammatory response IBA GO:0034136 negative regulation of toll-like receptor 2 signaling pathway IGI GO:0035666 TRIF-dependent toll-like receptor signaling pathway ISS GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway IDA GO:0043032 positive regulation of macrophage activation ISS GO:0045087 innate immune response NAS GO:1900017 positive regulation of cytokine production involved in inflammatory response ISS GO:1900227 positive regulation of NLRP3 inflammasome complex assembly ISS click arrow to show/hide IEA associations GO:0001774 microglial cell activation IEA

Clinically-Relevant Mutations and Pathophysiology
Disease:  Aspergillosis Disease Ontology: DOID:13564
Disease:  Asthma, susceptibility to Disease Ontology: DOID:2841 OMIM: 600807
Disease:  Prostate cancer Disease Ontology: DOID:10283 OMIM: 176807