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target has curated data in GtoImmuPdb
Target id: 1875
Nomenclature: Fas
Systematic Nomenclature: TNFRSF6
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 1 | 335 | 10q23.31 | FAS | Fas cell surface death receptor | |
| Mouse | 1 | 327 | 19 29.48 cM | Fas | Fas cell surface death receptor | |
| Rat | 1 | 324 | 1q52 | Fas | Fas cell surface death receptor | |
| Previous and Unofficial Names |
| APO-1 | CD95 | apoptosis-mediating surface antigen FAS | Fas receptor | FASLG receptor | Fas cell surface death receptor | FAS1 | TNFRSF6A | Fas (TNF receptor superfamily member 6) |
| Database Links |
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| Alphafold | P25445 (Hs), P25446 (Mm), Q63199 (Rn) |
| ChEMBL Target | CHEMBL4523207 (Hs), CHEMBL2417350 (Rn) |
| Ensembl Gene | ENSG00000026103 (Hs), ENSMUSG00000024778 (Mm), ENSRNOG00000019142 (Rn) |
| Entrez Gene | 355 (Hs), 14102 (Mm), 246097 (Rn) |
| Human Protein Atlas | ENSG00000026103 (Hs) |
| KEGG Gene | hsa:355 (Hs), mmu:14102 (Mm), rno:246097 (Rn) |
| OMIM | 134637 (Hs) |
| Pharos | P25445 (Hs) |
| UniProtKB | P25445 (Hs), P25446 (Mm), Q63199 (Rn) |
| Wikipedia | FAS (Hs) |
| Natural/Endogenous Ligands |
| Fas ligand {Sp: Human} |
| Adaptor proteins (Human) |
| FADD |
| Immunopharmacology Comments |
| Fas receptor (CD95) is a cell surface protein that belongs to the tumor necrosis factor receptor family, that along with its ligand CD95L, generates a death receptor/death ligand system that mediates apoptosis induction to maintain immune homeostasis. This system is also important in the immune elimination of virus-infected cells, cancer cells and autoreactive T cells. Mouse strains with mutations in Fas or CD95L develop lymphoproliferative conditions, indicating the importance of these proteins to immune cell homeostasis [2]. The phenotype of Fas-mutant mice presents in a systemic lupus erythematosus-like autoimmune disease [3]. Fas or CD95L knockout mice show a more severe autoimmune phenotype than the mutant mice mentioned. Humans with type 1a and 1b autoimmune lymphoproliferative syndrome (ALPS) carry mutations in Fas and CD95L respectively. |
| Immuno Process Associations | |||||||||
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| Immuno Disease Associations | ||||||||||
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| Phenotypes, Alleles and Disease Models
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Mouse data from MGI | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Clinically-Relevant Mutations and Pathophysiology
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1. Bidère N, Su HC, Lenardo MJ. (2006) Genetic disorders of programmed cell death in the immune system. Annu Rev Immunol, 24: 321-52. [PMID:16551252]
2. Takahashi T, Tanaka M, Brannan CI, Jenkins NA, Copeland NG, Suda T, Nagata S. (1994) Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell, 76 (6): 969-76. [PMID:7511063]
3. Watanabe-Fukunaga R, Brannan CI, Copeland NG, Jenkins NA, Nagata S. (1992) Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature, 356 (6367): 314-7. [PMID:1372394]
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