interleukin 1 receptor associated kinase 2 | Interleukin-1 receptor-associated kinase (IRAK) family | IUPHAR/BPS Guide to PHARMACOLOGY

Top ▲

interleukin 1 receptor associated kinase 2

target has curated data in GtoImmuPdb

Target id: 2043

Nomenclature: interleukin 1 receptor associated kinase 2

Abbreviated Name: IRAK2

Family: Interleukin-1 receptor-associated kinase (IRAK) family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 625 3p25.2 IRAK2 interleukin 1 receptor associated kinase 2
Mouse - 622 6 E3 Irak2 interleukin-1 receptor-associated kinase 2
Rat - 624 4 q42 Irak2 interleukin-1 receptor-associated kinase 2
Previous and Unofficial Names
interleukin-1 receptor-associated kinase 2
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  The ternary Death Domain complex of MyD88, IRAK4, and IRAK2
PDB Id:  3MOP
Resolution:  3.4Å
Species:  Human
References:  1
Enzyme Reaction
EC Number: 2.7.11.1
Immunopharmacology Comments
IRAK2 is one of the proximal mediators of IL-1 signalling via the IL-1 receptor, the other being IRAK1. It plays a part in IL-1-induced upregulation of the transcription factor NF-κB. IRAK2 interacts with TRAF6 and Myd88.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 5 GO processes
GO:0002224 toll-like receptor signaling pathway TAS
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS
GO:0006954 inflammatory response TAS
GO:0034162 toll-like receptor 9 signaling pathway TAS
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway TAS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 4 GO processes
GO:0002224 toll-like receptor signaling pathway TAS
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS
GO:0034162 toll-like receptor 9 signaling pathway TAS
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway TAS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 4 GO processes
GO:0001959 regulation of cytokine-mediated signaling pathway IMP
GO:0019221 cytokine-mediated signaling pathway IBA
GO:0070498 interleukin-1-mediated signaling pathway IMP
GO:0070555 response to interleukin-1 IMP
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 4 GO processes
GO:0002224 toll-like receptor signaling pathway TAS
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS
GO:0034162 toll-like receptor 9 signaling pathway TAS
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway TAS

References

Show »

1. Lin SC, Lo YC, Wu H. (2010) Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature, 465 (7300): 885-90. [PMID:20485341]

How to cite this page

Interleukin-1 receptor-associated kinase (IRAK) family: interleukin 1 receptor associated kinase 2. Last modified on 17/10/2018. Accessed on 21/10/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2043.