Top ▲

CD2

Click here for help

Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2600

Nomenclature: CD2

Family: CD molecules

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 351 1p13.1 CD2 CD2 molecule
Mouse 1 344 3 44.17 cM Cd2 CD2 antigen
Rat 1 344 2q34 Cd2 Cd2 molecule
Database Links Click here for help
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
alefacept Peptide Approved drug Primary target of this compound Immunopharmacology Ligand Hs Inhibition - - 1-2
[1-2]
Immunopharmacology Comments
CD2 is a cell surface glycoprotein expressed on most human T cells and natural killer (NK) cells [3] as well as by the majority of T cell lymphomas and leukemias. CD2 functions as a cell adhesion and co-stimulatory molecule. It is known to bind lymphocyte function-associated antigen-3 (LFA-3/CD58), a surface molecule expressed by antigen presenting cells and epithelial cells. The CD2/CD58 interaction promotes the initial stages of cell contact and facilitates T-cell receptor (TCR) triggering. CD2 is used as a specific marker for T cells and NK cells, and to distinguish B cell neoplasms from T cell lymphomas and leukemias.
Cell Type Associations
Immuno Cell Type:  B cells
Immuno Cell Type:  T cells
Immuno Cell Type:  Natural killer cells
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 2 GO processes
GO:0030887 positive regulation of myeloid dendritic cell activation NAS
GO:0050900 leukocyte migration TAS
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 2 GO processes
GO:0042110 T cell activation TAS
GO:0045580 regulation of T cell differentiation NAS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes
GO:0030887 positive regulation of myeloid dendritic cell activation NAS
GO:0045580 regulation of T cell differentiation NAS
Immuno Process:  Immune system development
GO Annotations:  Associated to 1 GO processes
GO:0045580 regulation of T cell differentiation NAS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0032760 positive regulation of tumor necrosis factor production IDA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes
GO:0050900 leukocyte migration TAS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 4 GO processes
GO:0030101 natural killer cell activation NAS
GO:0030887 positive regulation of myeloid dendritic cell activation NAS
GO:0042110 T cell activation TAS
GO:0045580 regulation of T cell differentiation NAS
Immuno Disease Associations
Disease Name:  Psoriasis
Disease Synonyms:  no synonynms
Comment:  CD2 is the molecular target of alefacept, a drug that was approved for the treatment of moderate to severe plaque psoriasis.
Disease X-refs:  Disease Ontology: DOID:8893
References: 
General Comments
This protein contains an immunoglobulin (Ig)-like domain that resembles the antibody variable domain, that has been coined the 'V-set domain'. The genes for all human V-set domain containing proteins are listed in HGNC gene group 590.

References

Show »

1. da Silva AJ, Brickelmaier M, Majeau GR, Li Z, Su L, Hsu YM, Hochman PS. (2002) Alefacept, an immunomodulatory recombinant LFA-3/IgG1 fusion protein, induces CD16 signaling and CD2/CD16-dependent apoptosis of CD2(+) cells. J. Immunol., 168 (9): 4462-71. [PMID:11970990]

2. Mitchell P. (2002) First biotech drug to treat psoriasis. Nat. Biotechnol., 20 (7): 640-1. [PMID:12089534]

3. Yang JJ, Ye Y, Carroll A, Yang W, Lee HW. (2001) Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation. Curr. Protein Pept. Sci., 2 (1): 1-17. [PMID:12369898]

How to cite this page

CD molecules: CD2. Last modified on 07/08/2019. Accessed on 30/11/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2600.