Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	351	1p13.1	CD2	CD2 molecule
Mouse	1	344	3 44.17 cM	Cd2	CD2 antigen
Rat	1	344	2q34	Cd2	Cd2 molecule

Database Links
Alphafold	P06729 (Hs), P08920 (Mm), P08921 (Rn)
CATH/Gene3D	2.60.40.10
ChEMBL Target	CHEMBL2040 (Hs)
DrugBank Target	P06729 (Hs)
Ensembl Gene	ENSG00000116824 (Hs), ENSMUSG00000027863 (Mm), ENSRNOG00000015821 (Rn)
Entrez Gene	914 (Hs), 12481 (Mm), 497761 (Rn)
Human Protein Atlas	ENSG00000116824 (Hs)
KEGG Gene	hsa:914 (Hs), mmu:12481 (Mm), rno:497761 (Rn)
OMIM	186990 (Hs)
Pharos	P06729 (Hs)
RefSeq Nucleotide	NM_001767 (Hs), NM_013486 (Mm), NM_012830 (Rn)
RefSeq Protein	NP_001758 (Hs), NP_038514 (Mm), NP_036962 (Rn)
UniProtKB	P06729 (Hs), P08920 (Mm), P08921 (Rn)
Wikipedia	CD2 (Hs)

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Reference alefacept Hs Inhibition - - 1-2 ⤷ [1-2]

Immunopharmacology Comments

CD2 is a cell surface glycoprotein expressed on most human T cells and natural killer (NK) cells [3] as well as by the majority of T cell lymphomas and leukemias. CD2 functions as a cell adhesion and co-stimulatory molecule. It is known to bind lymphocyte function-associated antigen-3 (LFA-3/CD58), a surface molecule expressed by antigen presenting cells and epithelial cells. The CD2/CD58 interaction promotes the initial stages of cell contact and facilitates T-cell receptor (TCR) triggering. CD2 is used as a specific marker for T cells and NK cells, and to distinguish B cell neoplasms from T cell lymphomas and leukemias.

Cell Type Associations

Immuno Cell Type:  B cells

Immuno Cell Type:  T cells

Immuno Cell Type:  Natural killer cells

Immuno Process Associations

Immuno Process:  Inflammation GO Annotations:  Associated to 2 GO processes GO:0030887 positive regulation of myeloid dendritic cell activation NAS GO:0050900 leukocyte migration TAS

Immuno Process:  T cell (activation) GO Annotations:  Associated to 2 GO processes GO:0042110 T cell activation TAS GO:0045580 regulation of T cell differentiation NAS

Immuno Process:  Immune regulation GO Annotations:  Associated to 2 GO processes GO:0030887 positive regulation of myeloid dendritic cell activation NAS GO:0045580 regulation of T cell differentiation NAS

Immuno Process:  Immune system development GO Annotations:  Associated to 1 GO processes GO:0045580 regulation of T cell differentiation NAS

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 3 GO processes GO:0032729 positive regulation of interferon-gamma production IDA GO:0032757 positive regulation of interleukin-8 production IMP GO:0032760 positive regulation of tumor necrosis factor production IDA

Immuno Process:  Chemotaxis & migration GO Annotations:  Associated to 1 GO processes GO:0050900 leukocyte migration TAS

Immuno Process:  Cellular signalling GO Annotations:  Associated to 4 GO processes GO:0030101 natural killer cell activation NAS GO:0030887 positive regulation of myeloid dendritic cell activation NAS GO:0042110 T cell activation TAS GO:0045580 regulation of T cell differentiation NAS

Immuno Disease Associations

Disease Name:  Psoriasis Disease Synonyms:  no synonynms Comment:  CD2 is the molecular target of alefacept, a drug that was approved for the treatment of moderate to severe plaque psoriasis. Disease X-refs:  Disease Ontology: DOID:8893 References:

General Comments
This protein contains an immunoglobulin (Ig)-like domain that resembles the antibody variable domain, that has been coined the 'V-set domain'. The genes for all human V-set domain containing proteins are listed in HGNC gene group 590.