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CD molecules C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Cluster of differentiation refers to an attempt to catalogue systematically a series of over 300 cell-surface proteins associated with immunotyping. Many members of the group have identified functions as enzymes (for example, see CD73 ecto-5'-nucleotidase) or receptors (for example, see CD41 integrin, alpha 2b subunit). Many CDs are targeted for therapeutic gain using antibodies for the treatment of proliferative disorders. A full listing of all the Clusters of Differentiation proteins is not possible in the Guide to PHARMACOLOGY; listed herein are selected members of the family targeted for therapeutic gain.

Targets

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CD1d molecule Show summary » More detailed page go icon to follow link

CD2 C Show summary » More detailed page go icon to follow link

CD3e C Show summary » More detailed page go icon to follow link

CD4 Show summary » More detailed page go icon to follow link

CD6 C Show summary » More detailed page go icon to follow link

CD14 molecule Show summary » More detailed page go icon to follow link

Fc fragment of IgG receptor IIIa / CD16A Show summary » More detailed page go icon to follow link

CD19 Show summary » More detailed page go icon to follow link

CD20 (membrane-spanning 4-domains, subfamily A, member 1) C Show summary » More detailed page go icon to follow link

SIGLEC2 (CD22) Show summary » More detailed page go icon to follow link

CD28 Show summary » More detailed page go icon to follow link

SIGLEC3 (CD33) C Show summary » More detailed page go icon to follow link

CD36 molecule Show summary » More detailed page go icon to follow link

CD37 (CD37 molecule) Show summary » More detailed page go icon to follow link

CD38 Show summary » More detailed page go icon to follow link

CD47 Show summary » More detailed page go icon to follow link

CD52 C Show summary » More detailed page go icon to follow link

NCAM1 (neural cell adhesion molecule 1 (CD56)) Show summary » More detailed page go icon to follow link

P-selectin (CD62) Show summary » More detailed page go icon to follow link

CD66e (CEACAM5) Show summary » More detailed page go icon to follow link

CD74 Show summary » More detailed page go icon to follow link

CD79B Show summary » More detailed page go icon to follow link

CD80 C Show summary » More detailed page go icon to follow link

LILRB1 (leukocyte immunoglobulin like receptor B1 (CD85j)) Show summary » More detailed page go icon to follow link

LILRA4 (leukocyte immunoglobulin like receptor A4 (CD85g)) Show summary » More detailed page go icon to follow link

CD86 C Show summary » More detailed page go icon to follow link

FcαRI (Fc fragment of IgA receptor / CD89) Show summary » More detailed page go icon to follow link

semaphorin 4D (CD100) Show summary » More detailed page go icon to follow link

endoglin (CD105) Show summary » More detailed page go icon to follow link

basigin (Ok blood group) / CD147 Show summary » More detailed page go icon to follow link

CTLA-4 (cytotoxic T-lymphocyte-associated protein 4 (CD152)) C Show summary » More detailed page go icon to follow link

KIR3DL2 (CD158K) Show summary » More detailed page go icon to follow link

NKG2A (killer cell lectin like receptor C1 (CD159a) / CD159a) Show summary » More detailed page go icon to follow link

SIRPA (CD172a) Show summary » More detailed page go icon to follow link

LAG3 (CD223) / CD223 Show summary » More detailed page go icon to follow link

T-cell surface glycoprotein CD3 zeta chain (CD247) Show summary » More detailed page go icon to follow link

B7-H3 (CD276) Show summary » More detailed page go icon to follow link

ICOS (CD278) Show summary » More detailed page go icon to follow link

PD-1 (programmed cell death 1 (CD279)) C Show summary » More detailed page go icon to follow link

CD300a C Show summary » More detailed page go icon to follow link

LAIR1 (leukocyte associated immunoglobulin like receptor 1 (CD305)) Show summary » More detailed page go icon to follow link

CS1 (CD319) Show summary » More detailed page go icon to follow link

NKp30 (Natural cytotoxicity triggering receptor 3 (CD337)) Show summary » More detailed page go icon to follow link

TIM3 (CD366) Show summary » More detailed page go icon to follow link

Comments

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Further reading

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References

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How to cite this family page

Database page citation:

CD molecules. Accessed on 03/03/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=852.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.