labetuzumab   Click here for help

GtoPdb Ligand ID: 8251

Synonyms: CEACIDE® | hMN14
Compound class: Antibody
Comment: Labetuzumab is a humanised mouse monoclonal antibody targeting CEACAM5 (CD66e), a tumour marker that can be measured in serum.
Labetuzumab can be labelled with radioactive isotopes such as yttrium-90 and iodine-131, providing targeted radioimmumotherapy.
Labetuzumab has been used to generate an antibody-drug conjugate (ADC) called labetuzumab govitecan, in which the antibody is covalently bound to SN-38, the active metabolite of the topoisomerase inhibitor, irinotecan.
Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
8127 labetuzumab
Synonyms Click here for help
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 62
Other databases
GtoPdb PubChem SID 249565931
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Wikipedia Labetuzumab