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Interleukin 17 receptor A

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1738

Nomenclature: Interleukin 17 receptor A

Family: IL-17 receptor family

Contents:

Quaternary Structure: Complexes
Interleukin-17 receptor
Interleukin-25 receptor
Interleukin-17C receptor
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 866 22q11.1 IL17RA interleukin 17 receptor A
Mouse 1 864 6 56.95 cM Il17ra interleukin 17 receptor A
Rat - - Il17ra interleukin 17 receptor A
Previous and Unofficial Names Click here for help
CD217 | VDw217 | Interleukin-17 α receptor
Database Links Click here for help
Alphafold Q96F46 (Hs), Q60943 (Mm)
ChEMBL Target CHEMBL3580485 (Hs)
Ensembl Gene ENSG00000177663 (Hs), ENSMUSG00000002897 (Mm), ENSRNOG00000011153 (Rn)
Entrez Gene 23765 (Hs), 16172 (Mm), 312679 (Rn)
Human Protein Atlas ENSG00000177663 (Hs)
KEGG Gene hsa:23765 (Hs), mmu:16172 (Mm), rno:312679 (Rn)
OMIM 605461 (Hs)
Pharos Q96F46 (Hs)
UniProtKB Q96F46 (Hs), Q60943 (Mm)
Wikipedia IL17RA (Hs)

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Antibodies
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Antibody Sp. Action Value Parameter Reference
brodalumab Peptide Approved drug Primary target of this compound Immunopharmacology Ligand Hs Binding 9.2 pKd 1
⤷ pKd 9.2 (Kd 6.9x10-10 M) [1]
Immunopharmacology Comments
This protein is a common subunit shared by the heterodimeric receptors for interleukins 17 (A, B , C and F) and 25.

References

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1. Tocker J, Mehlin C, Lim AC. (2010) Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto. Patent number: US7767206. Assignee: Amgen Inc.. Priority date: 02/10/2006. Publication date: 03/08/2010.

How to cite this page

IL-17 receptor family: Interleukin 17 receptor A. Last modified on 07/04/2017. Accessed on 04/11/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1738.