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DExD/H-box helicase 58

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2920

Nomenclature: DExD/H-box helicase 58

Abbreviated Name: RIG-1

Family: RIG-I-like receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 925 9p21.1 RIGI RNA sensor RIG-I
Mouse - 926 4 A5 Rigi RNA sensor RIG-I
Rat - 598 5q22 Rig1 RNA sensor RIG-1
Previous and Unofficial Names Click here for help
DEAD/H box helicase 58 | DDX58 | Ddx58 | DEXD/H-box helicase 58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | retinoic acid inducible gene I | RNA helicase RIG-I
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number:
Description Reaction Reference
RNA helicase: uses the energy from ATP hydrolysis to unwind RNA ATP + H(2)O <=> ADP + phosphate

Download all structure-activity data for this target as a CSV file go icon to follow link

Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
SLR14 Small molecule or natural product Hs Agonist - - 1
Immunopharmacology Comments
RIG-I is an intracellular sensor that responds to viral nucleic acids and activates downstream signaling, resulting in the induction of the type I interferon response [2]. RIG-I recognizes RNAs from more that 25 viruses and can detect dsRNAs, ssRNAs harboring a 5′-triphosphate and blunt-ended 5′-triphosphate-containing dsRNAs. Dysregulated RIG-I signaling has been associated with autoimmune disorders [2].
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0039529 RIG-I signaling pathway IDA
GO:0045087 innate immune response IMP
GO:0140374 antiviral innate immune response IDA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes
GO:0002735 positive regulation of myeloid dendritic cell cytokine production ISS
GO:0039529 RIG-I signaling pathway IDA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 10 GO processes
GO:0002735 positive regulation of myeloid dendritic cell cytokine production ISS
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production IDA
GO:0032727 positive regulation of interferon-alpha production IDA
GO:0032728 positive regulation of interferon-beta production IDA
GO:0032755 positive regulation of interleukin-6 production IDA
GO:0032757 positive regulation of interleukin-8 production IDA
GO:0032760 positive regulation of tumor necrosis factor production IMP
GO:0034344 regulation of type III interferon production TAS
GO:0039529 RIG-I signaling pathway IDA
GO:0060760 positive regulation of response to cytokine stimulus IMP
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0039529 RIG-I signaling pathway IDA
Physiological Consequences of Altering Gene Expression Click here for help
Conventional dendritic cells (cDCs), macrophages and fibroblasts isolated from RIG-1 null mice have impaired IFN induction after RNA virus infection. Plasmacytoid DCs are unaffected by RIG-1 knockout, suggesting nucleic acid sensing TLRs are more relevant in these cells.
Species:  Mouse
Tissue:  cDCs, macrophages and fibroblasts,


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1. Mao T, Israelow B, Lucas C, Vogels CBF, Gomez-Calvo ML, Fedorova O, Breban MI, Menasche BL, Dong H, Linehan M et al.. (2022) A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice. J Exp Med, 219 (1) Epub ahead of print. DOI: 10.1084/jem.20211818 [PMID:34757384]

2. Matsumiya T, Stafforini DM. (2010) Function and regulation of retinoic acid-inducible gene-I. Crit Rev Immunol, 30 (6): 489-513. [PMID:21175414]

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