RIG-I-like receptor family C
Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Overview
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There are three human RIG-I-like receptors (RLRs) which are cytoplasmic pattern recognition receptors (PRRs) of the innate immune system. They detect non-self cytosolic double-stranded RNA species and and 5'-triphosphate single-stranded RNA from various sources and are essential for inducing production of type I interferons, such as IFNβ, type III interferons, and other anti-pathogenic effectors [1-2]. They function as RNA helicases (EC 3.6.4.13) using the energy from ATP hydrolysis to unwind RNA.
Receptors
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RIG-1 (DExD/H-box helicase 58)
C
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MDA5 (interferon induced with helicase C domain 1)
C
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LGP2 (DExH-box helicase 58)
C
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Further reading
How to cite this family page
Database page citation (select format):
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. Br J Pharmacol. 180 Suppl 2:S241-288.
