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DExH-box helicase 58

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2922

Nomenclature: DExH-box helicase 58

Abbreviated Name: LGP2

Family: RIG-I-like receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 678 17q21.2 DHX58 DExH-box helicase 58
Mouse - 678 11 D; 11 63.52 cM Dhx58 DEXH (Asp-Glu-X-His) box polypeptide 58
Rat - 678 10q31 Dhx58 DEXH-box helicase 58
Previous and Unofficial Names Click here for help
DEXH (Asp-Glu-X-His) box polypeptide 58 | RNA helicase LGP2
Database Links Click here for help
Alphafold
BRENDA
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.6.4.13
Description Reaction Reference
RNA helicase: uses the energy from ATP hydrolysis to unwind RNA ATP + H(2)O <=> ADP + phosphate
Immunopharmacology Comments
LGP2 binds RNA but does not participate in the signaling pathway that RIG-1 and MDA5 are part of, and is assumed to provide a negative feedback for IFNβ induction by sequestering pathogen-derived RNA.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 6 GO processes
GO:0039534 negative regulation of MDA-5 signaling pathway IMP
GO:0039536 negative regulation of RIG-I signaling pathway IDA
GO:0045088 regulation of innate immune response IDA
GO:0045824 negative regulation of innate immune response IDA
GO:1900245 positive regulation of MDA-5 signaling pathway ISS
click arrow to show/hide IEA associations
GO:0045087 innate immune response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 5 GO processes
GO:0039534 negative regulation of MDA-5 signaling pathway IMP
GO:0039536 negative regulation of RIG-I signaling pathway IDA
GO:0045088 regulation of innate immune response IDA
GO:0045824 negative regulation of innate immune response IDA
GO:1900245 positive regulation of MDA-5 signaling pathway ISS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 6 GO processes
GO:0032480 negative regulation of type I interferon production IDA
GO:0032481 positive regulation of type I interferon production ISS
GO:0032728 positive regulation of interferon-beta production IBA
GO:0039534 negative regulation of MDA-5 signaling pathway IMP
GO:0039536 negative regulation of RIG-I signaling pathway IDA
GO:1900245 positive regulation of MDA-5 signaling pathway ISS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 3 GO processes
GO:0039534 negative regulation of MDA-5 signaling pathway IMP
GO:0039536 negative regulation of RIG-I signaling pathway IDA
GO:1900245 positive regulation of MDA-5 signaling pathway ISS

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