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DExD/H-box helicase 58

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2920

Nomenclature: DExD/H-box helicase 58

Abbreviated Name: RIG-1

Family: RIG-I-like receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 925 9p21.1 RIGI RNA sensor RIG-I
Mouse - 926 4 A5 Rigi RNA sensor RIG-I
Rat - 598 5q22 Rig1 RNA sensor RIG-1
Previous and Unofficial Names Click here for help
DEAD/H box helicase 58 | DDX58 | Ddx58 | DEXD/H-box helicase 58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | retinoic acid inducible gene I | RNA helicase RIG-I
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number:
Description Reaction Reference
RNA helicase: uses the energy from ATP hydrolysis to unwind RNA ATP + H(2)O <=> ADP + phosphate

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Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
SLR14 Small molecule or natural product Hs Agonist - - 1
Immunopharmacology Comments
RIG-I is an intracellular sensor that responds to viral nucleic acids and activates downstream signaling, resulting in the induction of the type I interferon response [2]. RIG-I recognizes RNAs from more that 25 viruses and can detect dsRNAs, ssRNAs harboring a 5′-triphosphate and blunt-ended 5′-triphosphate-containing dsRNAs. Dysregulated RIG-I signaling has been associated with autoimmune disorders [2].
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Immune regulation
Immuno Process:  Cytokine production & signalling
Immuno Process:  Cellular signalling
Physiological Consequences of Altering Gene Expression Click here for help
Conventional dendritic cells (cDCs), macrophages and fibroblasts isolated from RIG-1 null mice have impaired IFN induction after RNA virus infection. Plasmacytoid DCs are unaffected by RIG-1 knockout, suggesting nucleic acid sensing TLRs are more relevant in these cells.
Species:  Mouse
Tissue:  cDCs, macrophages and fibroblasts,


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1. Mao T, Israelow B, Lucas C, Vogels CBF, Gomez-Calvo ML, Fedorova O, Breban MI, Menasche BL, Dong H, Linehan M et al.. (2022) A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice. J Exp Med, 219 (1). [PMID:34757384]

2. Matsumiya T, Stafforini DM. (2010) Function and regulation of retinoic acid-inducible gene-I. Crit Rev Immunol, 30 (6): 489-513. [PMID:21175414]

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