TLR6 | Toll-like receptor family | IUPHAR/BPS Guide to PHARMACOLOGY

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TLR6

target has curated data in GtoImmuPdb

Target id: 1756

Nomenclature: TLR6

Family: Toll-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 765 4p14 TLR6 toll like receptor 6
Mouse - 768 5 33.54 cM Tlr6 toll-like receptor 6
Rat - - 14p11 Tlr6 toll-like receptor 6
Previous and Unofficial Names
CD286 | toll-like receptor 6
Database Links
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Immunopharmacology Comments
TLR6 forms heterodimers with TLR2 to detect a wide range of bacterial lipopeptides (LP) from bacterial cell membranes, and effect an immune response [1]. TLR2/6 dimers perferentially detect diacylated LP [2]. Pam2Cys-SKKKK is a synthetic LP which induces signalling through TLR2/TLR6 heteromers. Activation of TLR2-TLR6 heteromers by LP promotes formation of a functional signalling complex that includes MyD88 and IL-1R-associated kinase (IRAK) proteins, that ultimately initiates NF-κB-mediated cytokine production.
Cell Type Associations
Immuno Cell Type:  Dendritic cells
Cell Ontology Term:   dendritic cell (CL:0000451)
Comment:  NB monocyte-derived immature DCs.
References:  2
Immuno Cell Type:  Macrophages & monocytes
Cell Ontology Term:   monocyte (CL:0000576)
References:  2
Immuno Cell Type:  Granulocytes
Cell Ontology Term:   neutrophil (CL:0000775)
References:  2
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 11 GO processes
GO:0002224 toll-like receptor signaling pathway IBA
GO:0002755 MyD88-dependent toll-like receptor signaling pathway ISS
GO:0006954 inflammatory response IBA
GO:0034136 negative regulation of toll-like receptor 2 signaling pathway IGI
GO:0035666 TRIF-dependent toll-like receptor signaling pathway ISS
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway TAS
GO:0043032 positive regulation of macrophage activation ISS
GO:1900017 positive regulation of cytokine production involved in inflammatory response ISS
click arrow to show/hide IEA associations
GO:0001774 microglial cell activation IEA
GO:0034150 toll-like receptor 6 signaling pathway IEA
GO:0045087 innate immune response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 8 GO processes
GO:0002224 toll-like receptor signaling pathway IBA
GO:0002755 MyD88-dependent toll-like receptor signaling pathway ISS
GO:0034136 negative regulation of toll-like receptor 2 signaling pathway IGI
GO:0035666 TRIF-dependent toll-like receptor signaling pathway ISS
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway TAS
GO:0043032 positive regulation of macrophage activation ISS
GO:1900017 positive regulation of cytokine production involved in inflammatory response ISS
click arrow to show/hide IEA associations
GO:0034150 toll-like receptor 6 signaling pathway IEA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 4 GO processes
GO:0045410 positive regulation of interleukin-6 biosynthetic process ISS
GO:0050702 interleukin-1 beta secretion ISS
GO:1900017 positive regulation of cytokine production involved in inflammatory response ISS
GO:2000483 negative regulation of interleukin-8 secretion IGI
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 8 GO processes
GO:0002224 toll-like receptor signaling pathway IBA
GO:0002755 MyD88-dependent toll-like receptor signaling pathway ISS
GO:0034136 negative regulation of toll-like receptor 2 signaling pathway IGI
GO:0035666 TRIF-dependent toll-like receptor signaling pathway ISS
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway TAS
GO:0043032 positive regulation of macrophage activation ISS
click arrow to show/hide IEA associations
GO:0001774 microglial cell activation IEA
GO:0034150 toll-like receptor 6 signaling pathway IEA
Clinically-Relevant Mutations and Pathophysiology
Disease:  Aspergillosis
Disease Ontology: DOID:13564
Disease:  Asthma, susceptibility to
Disease Ontology: DOID:2841
OMIM: 600807
Disease:  Prostate cancer
Disease Ontology: DOID:10283
OMIM: 176807

References

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1. Farhat K, Riekenberg S, Heine H, Debarry J, Lang R, Mages J, Buwitt-Beckmann U, Röschmann K, Jung G, Wiesmüller KH et al.. (2008) Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling. J. Leukoc. Biol., 83 (3): 692-701. [PMID:18056480]

2. Nakao Y, Funami K, Kikkawa S, Taniguchi M, Nishiguchi M, Fukumori Y, Seya T, Matsumoto M. (2005) Surface-expressed TLR6 participates in the recognition of diacylated lipopeptide and peptidoglycan in human cells. J. Immunol., 174 (3): 1566-73. [PMID:15661917]

Contributors

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