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target has curated data in GtoImmuPdb
Target id: 2791
Nomenclature: baculoviral IAP repeat containing 2
Family: Inhibitors of apoptosis (IAP) protein family
Annotation status:
Awaiting annotation/under development. Please contact us if you can help with annotation.
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Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 618 | 11q22 | BIRC2 | baculoviral IAP repeat containing 2 | |
Mouse | - | 612 | 9 A1 | Birc2 | baculoviral IAP repeat-containing 2 | |
Rat | - | 589 | 8q11 | Birc2 | baculoviral IAP repeat-containing 2 |
Previous and Unofficial Names ![]() |
c-IAP1 | cIAP1 | MIHB | API1 |
Database Links ![]() |
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CATH/Gene3D | 3.30.40.10 |
ChEMBL Target | CHEMBL5462 (Hs) |
Ensembl Gene | ENSG00000110330 (Hs), ENSMUSG00000057367 (Mm), ENSRNOG00000010602 (Rn) |
Entrez Gene | 329 (Hs), 11797 (Mm), 60371 (Rn) |
Human Protein Atlas | ENSG00000110330 (Hs) |
KEGG Gene | hsa:329 (Hs), mmu:11797 (Mm), rno:60371 (Rn) |
OMIM | 601712 (Hs) |
RefSeq Nucleotide | NM_001166 (Hs), NM_007465 (Mm), NM_021752 (Rn) |
RefSeq Protein | NP_001157 (Hs), NP_031491 (Mm), NP_068520 (Rn) |
UniProtKB | Q13490 (Hs), Q62210 (Mm) |
Wikipedia | BIRC2 (Hs) |
Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Antagonists | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Antagonist Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
AZD5582 is a peptide mimetic. It consists of a dimeric structure, with sequences based on the AVPI motif of DIABLO (aka Smac; Q9NR28). DIABLO is a peptide of mitochondrial origin and is an endogenous pro-apoptotic antagonist of IAP protein function. |
Immunopharmacology Comments |
Cellular inhibitors of apoptosis proteins BIRC2 and BIRC3 are required for efficient caspase-1 activation by the inflammasome [6], and represent novel drug targets in inflammatory processes [7]. |
Immuno Process Associations | |||||||||||||||||||||||||||||||||||||||||||||
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Physiological Consequences of Altering Gene Expression ![]() |
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1. Allensworth JL, Sauer SJ, Lyerly HK, Morse MA, Devi GR. (2013) Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-α-independent mechanism. Breast Cancer Res. Treat., 137 (2): 359-71. [PMID:23225169]
2. Cai Q, Sun H, Peng Y, Lu J, Nikolovska-Coleska Z, McEachern D, Liu L, Qiu S, Yang CY, Miller R et al.. (2011) A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment. J. Med. Chem., 54 (8): 2714-26. [PMID:21443232]
3. Donnell AF, Michoud C, Rupert KC, Han X, Aguilar D, Frank KB, Fretland AJ, Gao L, Goggin B, Hogg JH et al.. (2013) Benzazepinones and benzoxazepinones as antagonists of inhibitor of apoptosis proteins (IAPs) selective for the second baculovirus IAP repeat (BIR2) domain. J. Med. Chem., 56 (20): 7772-87. [PMID:24083782]
4. Flygare JA, Beresini M, Budha N, Chan H, Chan IT, Cheeti S, Cohen F, Deshayes K, Doerner K, Eckhardt SG et al.. (2012) Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152). J. Med. Chem., 55 (9): 4101-13. [PMID:22413863]
5. Hennessy EJ, Adam A, Aquila BM, Castriotta LM, Cook D, Hattersley M, Hird AW, Huntington C, Kamhi VM, Laing NM et al.. (2013) Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582). J. Med. Chem., 56 (24): 9897-919. [PMID:24320998]
6. Labbé K, McIntire CR, Doiron K, Leblanc PM, Saleh M. (2011) Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome. Immunity, 35 (6): 897-907. [PMID:22195745]
7. Mayer BA, Rehberg M, Erhardt A, Wolf A, Reichel CA, Kracht M, Krombach F, Tiegs G, Zahler S, Vollmar AM et al.. (2011) Inhibitor of apoptosis proteins as novel targets in inflammatory processes. Arterioscler. Thromb. Vasc. Biol., 31 (10): 2240-50. [PMID:21817100]
8. Peng Y, Sun H, Nikolovska-Coleska Z, Qiu S, Yang CY, Lu J, Cai Q, Yi H, Kang S, Yang D et al.. (2008) Potent, orally bioavailable diazabicyclic small-molecule mimetics of second mitochondria-derived activator of caspases. J. Med. Chem., 51 (24): 8158-62. [PMID:19049347]
9. Varfolomeev E, Blankenship JW, Wayson SM, Fedorova AV, Kayagaki N, Garg P, Zobel K, Dynek JN, Elliott LO, Wallweber HJ et al.. (2007) IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell, 131 (4): 669-81. [PMID:18022362]
Inhibitors of apoptosis (IAP) protein family: baculoviral IAP repeat containing 2. Last modified on 15/02/2017. Accessed on 13/12/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2791.