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Interleukin-31 receptor, α subunit

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1710

Nomenclature: Interleukin-31 receptor, α subunit

Family: IL-6 receptor family

Quaternary Structure: Complexes
Interleukin-31 receptor
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 732 5q11.2 IL31RA interleukin 31 receptor A
Mouse 1 716 13 D2.2 Il31ra interleukin 31 receptor A
Rat - 718 2q14 Il31ra interleukin 31 receptor A
Previous and Unofficial Names Click here for help
CRL | CRL3 | interleukin-31 receptor subunit alpha | GPL | Glmr | NR10 [1]
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein

Download all structure-activity data for this target as a CSV file go icon to follow link

Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
nemolizumab Peptide Approved drug Primary target of this compound Immunopharmacology Ligand Hs Binding 8.7 pKd 1
pKd 8.7 (Kd 2x10-9 M) [1]
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Immune regulation
Immuno Process:  Immune system development
Immuno Process:  Cytokine production & signalling
Immuno Process:  Cellular signalling
Immuno Process:  T cell (activation)
Immuno Process:  B cell (activation)
General Comments
The IL-31 receptor subunit α functions a monomer and as part of a receptor complex with the oncostatin M receptor (OSMR). It is a type I cytokine receptor that is involved in IL-31 signalling which is mediated via activation of STAT3 and STAT5.


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1. Kuramochi T, Kasutani K, Ohyama S, Tsunoda H, Igawa T, Tachibana T, Shiraiwa H, Esaki K. (2013) Anti-NR10 antibody and use thereof. Patent number: US8575317 B2. Assignee: Chugai Seiyaku Kabushiki Kaisha. Priority date: 05/12/2007. Publication date: 05/11/2013.

How to cite this page

IL-6 receptor family: Interleukin-31 receptor, α subunit. Last modified on 17/10/2018. Accessed on 23/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY,