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Fc fragment of IgG receptor IIIa

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 3017

Nomenclature: Fc fragment of IgG receptor IIIa

Systematic Nomenclature: CD16A

Family: CD molecules, Immunoglobulin like domain containing proteins

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 254 1q23.3 FCGR3A Fc fragment of IgG receptor IIIa
Mouse 1 249 1 78.53 cM Fcgr4 Fc receptor, IgG, low affinity IV
Rat 1 249 13q24 Fcgr3a Fc fragment of IgG receptor IIIa
Gene and Protein Information Comments
Alternatively spliced transcript variants encoding different isoforms have been reported for the human gene.
Previous and Unofficial Names Click here for help
Fc receptor, IgG, low affinity IV | Fc receptor | FCγRIIIa | FcRIIIA | low affinity immunoglobulin gamma Fc region receptor III-A
Database Links Click here for help
Alphafold
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file go icon to follow link

Antibodies
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Antibody Sp. Action Value Parameter Reference
AFM13 Peptide Primary target of this compound Click here for species-specific activity table Immunopharmacology Ligand Hs Binding 9.1 – 9.4 pKd 1
pKd 9.1 – 9.4 (Kd 8.4x10-10 – 3.9x10-10 M) [1]
Description: Binding to CD16a 158V and 158F proteins by SPR.
bemarituzumab Peptide Click here for species-specific activity table Hs Binding 8.0 pKd 2
pKd 8.0 (Kd 9.2x10-9 M) [2]
Description: Binding affinity of FcγRIIIa (V158) for immobilised antibody by SPR.
Immunopharmacology Comments
The FCGR3A gene is expressed by natural killer (NK) cells. The protein product (CD16A or FcγRIIIa) is an integral peptide-tethered membrane glycoprotein. FcγRIIIa is a low-affinity receptor for IgG Fc and is involved in removing antigen-antibody complexes from the circulation and antibody-dependent responses.

FcγRIIIa is being exploited for drug development, specifically as a NK cell-engager to mediate NK effector cell killing of cancer cells. For example, Affimed have developed AFM13, a tetravalent bispecific Fv peptide construct that simultaneously engages FcγRIIIa and CD30 on CD30-expressing malignant cells such as Hodgkin lymphoma cells, and AFM24 another tetravalent bispecific construct that targets epidermal growth factor receptor (EGFR) and FcγRIIIa to engage NK cells to destroy otherwise hard to treat EGFR-driven cancers.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
GO:0050776 regulation of immune response TAS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
General Comments
FcγRIIIa is an integral membrane glycoprotein anchored through a transmembrane peptide to the surface of natural killer (NK) cells.

References

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1. Reusch U, Burkhardt C, Fucek I, Le Gall F, Le Gall M, Hoffmann K, Knackmuss SH, Kiprijanov S, Little M, Zhukovsky EA. (2014) A novel tetravalent bispecific TandAb (CD30/CD16A) efficiently recruits NK cells for the lysis of CD30+ tumor cells. MAbs, 6 (3): 728-39. [PMID:24670809]

2. Xiang H, Liu L, Gao Y, Ahene A, Macal M, Hsu AW, Dreiling L, Collins H. (2020) Population pharmacokinetic analysis of phase 1 bemarituzumab data to support phase 2 gastroesophageal adenocarcinoma FIGHT trial. Cancer Chemother Pharmacol, 86 (5): 595-606. [PMID:32965540]

How to cite this page

CD molecules: Fc fragment of IgG receptor IIIa. Last modified on 12/10/2020. Accessed on 27/11/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3017.