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Synonyms: FPA-144 | FPA144
Compound class: Antibody
Comment: Bemarituzumab (FPA144) is first-in-class anti-fibroblast growth factor receptor 2b (FGFR2b) chemotherapy antibody from Five Prime Therapeutics . It is humanized and of the immunoglobulin G1 (IgG1) isotype. It binds to FGFR2b and promotes ADCC via enhanced binding to FcγRIIIa. Bemarituzumab is designed to target FGFR2b on cancer cells that use the FGF/FGFR pathway to promote transformation, proliferation and angiogenesis.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|International Nonproprietary Names|
|FPA-144 | FPA144|
|GtoPdb PubChem SID||434321713|
|Search PubMed clinical trials||bemarituzumab|
|Search PubMed titles||bemarituzumab|
|Search PubMed titles/abstracts||bemarituzumab|