Interleukin-6 receptor, β subunit | IL-6 receptor family | IUPHAR/BPS Guide to PHARMACOLOGY

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Interleukin-6 receptor, β subunit

target has curated data in GtoImmuPdb

Target id: 2317

Nomenclature: Interleukin-6 receptor, β subunit

Abbreviated Name: IL6ST

Systematic Nomenclature: interleukin 6 signal transducer

Family: IL-6 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Quaternary Structure: Complexes
Interleukin-6 receptor
Interleukin-11 receptor
Ciliary neutrophic factor receptor
Leukemia inhibitory factor receptor
Oncostatin-M receptor
Interleukin-27 receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 918 5q11.2 IL6ST interleukin 6 signal transducer
Mouse 1 917 13 63.73 cM Il6st interleukin 6 signal transducer
Rat 1 918 2q14-q16 Il6st interleukin 6 signal transducer
Previous and Unofficial Names
CD130 | gp130 | interleukin-6 receptor subunit beta | membrane glycoprotein 130 | oncostatin-M receptor subunit alpha | interleukin 6 signal transducer (gp130, oncostatin M receptor)
Database Links
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Human Protein Atlas
OMIM
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Cytokine-binding region of gp130
PDB Id:  1BQU
Resolution:  2.0Å
Species:  Human
References:  1
Immunopharmacology Comments
This is the common signal transducing subunit shared by members of the IL-6 family of cytokine receptors [2].
IL-6/IL-6R regulated signalling pathways represent a druggable target for the therapy of chronic inflammatory and autoimmune diseases, and cancer [3]. IL6ST (gp130) is being investigated as therapeutic target for the treatment of autoimmune diseases [3-4]. For example i-Mab Biopharma have a gp130 targeting Fc fusion protein (olamkicept; TJ301) in early stage clinical trial in patients with active ulcerative colitis (Ph2 NCT03235752).
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0002675 positive regulation of acute inflammatory response IC
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 2 GO processes
GO:0002821 positive regulation of adaptive immune response IC
GO:0042102 positive regulation of T cell proliferation IMP
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0002821 positive regulation of adaptive immune response IC
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes
GO:0002675 positive regulation of acute inflammatory response IC
GO:0002821 positive regulation of adaptive immune response IC
GO:0042102 positive regulation of T cell proliferation IMP
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 13 GO processes
GO:0004896 cytokine receptor activity IBA
GO:0004897 ciliary neurotrophic factor receptor activity IDA
GO:0010575 positive regulation of vascular endothelial growth factor production TAS
GO:0019221 cytokine-mediated signaling pathway IDA
GO:0034097 response to cytokine IDA
GO:0038165 oncostatin-M-mediated signaling pathway IMP
GO:0045509 interleukin-27 receptor activity IC
GO:0070102 interleukin-6-mediated signaling pathway IMP
GO:0070104 negative regulation of interleukin-6-mediated signaling pathway IDA
GO:0070106 interleukin-27-mediated signaling pathway IMP
GO:0070120 ciliary neurotrophic factor-mediated signaling pathway IDA
GO:0070757 interleukin-35-mediated signaling pathway TAS
click arrow to show/hide IEA associations
GO:0004921 interleukin-11 receptor activity IEA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes
GO:0042102 positive regulation of T cell proliferation IMP
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0042102 positive regulation of T cell proliferation IMP

References

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1. Bravo J, Staunton D, Heath JK, Jones EY. (1998) Crystal structure of a cytokine-binding region of gp130. EMBO J., 17 (6): 1665-74. [PMID:9501088]

2. Rose-John S. (2018) Interleukin-6 Family Cytokines. Cold Spring Harb Perspect Biol, 10 (2). [PMID:28620096]

3. Rose-John S, Waetzig GH, Scheller J, Grötzinger J, Seegert D. (2007) The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Expert Opin. Ther. Targets, 11 (5): 613-24. [PMID:17465721]

4. Shaw S, Bourne T, Meier C, Carrington B, Gelinas R, Henry A, Popplewell A, Adams R, Baker T, Rapecki S et al.. (2014) Discovery and characterization of olokizumab: a humanized antibody targeting interleukin-6 and neutralizing gp130-signaling. MAbs, 6 (3): 774-82. [PMID:24670876]

How to cite this page

IL-6 receptor family: Interleukin-6 receptor, β subunit. Last modified on 15/04/2019. Accessed on 18/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2317.