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Interleukin-6 receptor

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2310

Nomenclature: Interleukin-6 receptor

Family: IL-6 receptor family

Quaternary Structure: Subunits
Interleukin-6 receptor, α subunit (Ligand-binding subunit)
Interleukin-6 receptor, β subunit (Other subunit)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex
PDB Id:  1P9M
Resolution:  3.65Å
Species:  Human
References:  1
Natural/Endogenous Ligands Click here for help
IL-6 {Sp: Human}

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Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
vobarilizumab Peptide Primary target of this compound Immunopharmacology Ligand Hs Binding 12.7 pKd 5
pKd 12.7 (Kd 1.9x10-13 M) [5]
satralizumab Peptide Approved drug Primary target of this compound Immunopharmacology Ligand Hs Binding 8.9 pKd 2
pKd 8.9 (Kd 1.4x10-9 M) [2]
tocilizumab Peptide Approved drug Primary target of this compound Immunopharmacology Ligand Hs Binding 8.6 pKd
pKd 8.6 (Kd 2.54x10-9 M)
Immunopharmacology Comments
The IL-6 receptor is a complex of the IL6R α subunit (ligand binding subunit) and the IL6ST β subunit (signal transducer). IL6ST is shared with other cytokine receptor complexes. The endogenous ligand is IL-6. The IL-6 receptor also binds ciliary neurotrophic factor [3-4].

Biocad's anti-IL6R mAb levilimab (BCD-089) has reached Phase 2 clinical trial in patients with active, seropositive rheumatoid arthritis (see NCT03455842).

References

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1. Boulanger MJ, Chow DC, Brevnova EE, Garcia KC. (2003) Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex. Science, 300 (5628): 2101-4. [PMID:12829785]

2. Igawa T, Ishii S, Maeda A, Sakurai M, Kojima T, Tachibana T, Shiraiwa H, Tsunoda H, Higuchi Y. (2013) Antibody molecules that bind to IL-6 receptor. Patent number: US8562991 B2. Assignee: Chugai Seiyaku Kabushiki Kaisha. Priority date: 26/09/2008. Publication date: 22/10/2013.

3. Schooltink H, Stoyan T, Roeb E, Heinrich PC, Rose-John S. (1992) Ciliary neurotrophic factor induces acute-phase protein expression in hepatocytes. FEBS Lett, 314 (3): 280-4. [PMID:1281789]

4. Schuster B, Kovaleva M, Sun Y, Regenhard P, Matthews V, Grötzinger J, Rose-John S, Kallen KJ. (2003) Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF. J Biol Chem, 278 (11): 9528-35. [PMID:12643274]

5. Van Roy M, Ververken C, Beirnaert E, Hoefman S, Kolkman J, Vierboom M, Breedveld E, 't Hart B, Poelmans S, Bontinck L et al.. (2015) The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis. Arthritis Res Ther, 17: 135. [PMID:25994180]

How to cite this page

IL-6 receptor family: Interleukin-6 receptor. Last modified on 05/06/2019. Accessed on 20/05/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2310.