vobarilizumab   Click here for help

GtoPdb Ligand ID: 8363

Synonyms: ALX-0061
Immunopharmacology Ligand
Compound class: Antibody
Comment: Vobarilizumab is an investigational bispecific peptide NanobodyTM which binds soluble IL-6R and human albumin (albumin binding being utilised as a half-life extension methodology). Design and production of ALX-0061 is described in patent US8748581 [2]. Vobarilizumab is being developed for the treatment of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Preclinical information is published in [6].
The exact NanobodyTM structure being used as ALX-0061 was not revealed in the covering patent [2], but has been disclosed in the INN submission. Annotated peptide sequences for this therapeutic are available from its IMGT/mAb-DB record.
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Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
10210 vobarilizumab
Synonyms Click here for help
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 523
Other databases
GtoPdb PubChem SID 252166575
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