Ligand id: 4998

Name: IL-6

Species: Human

Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Interleukins
B-cell stimulatory factor 2 | CTL differentiation factor | hybridoma growth factor | interferon β2 | interleukin-6
IL-6 is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. It is the originating member of a family of related cytokines that include IL-11, oncostatin M (OSM), leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine factor 1/B-cell stimulating factor 3 (NNT-1), neuropoietin (NPN), IL-27, and IL-31 [11]. IL-6 is produced by T and B cells, macrophages, dendritic cells, and non-immune cells such as fibroblasts, endothelial cells, glial cells, keratinocytes, and placental syncytio- and extravillous trophoblasts.
The receptors for these cytokines (except IL-31) share a common signal transducing subunit gp130 (IL6ST).
IL-6 is a critical regulator of the immune system and has been widely implicated in autoimmune disease, infection responses and in the regulation of metabolic, regenerative, and neural processes.
Gene symbol Gene name Species Precursor protein name Synonyms
IL6 interleukin 6 Human prepro-interleukin 6 BSF2, HGF, HSF, IFNB2, IL-6, interleukin 6 (interferon, beta 2)
Database Links
GtoPdb PubChem SID 178101695
Immunopaedia Search IL-6
UniProtKB P05231 (Hs)
Wikipedia Interleukin_6