IL-6   

GtoPdb Ligand ID: 4998

Synonyms: B-cell stimulatory factor 2 | CTL differentiation factor | hybridoma growth factor | interferon β2 | interleukin-6
Comment: IL-6 is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. It is the originating member of a family of related cytokines that include IL-11, oncostatin M (OSM), leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine factor 1/B-cell stimulating factor 3 (NNT-1), neuropoietin (NPN), IL-27, and IL-31 [11]. IL-6 is produced by T and B cells, macrophages, dendritic cells, and non-immune cells such as fibroblasts, endothelial cells, glial cells, keratinocytes, and placental syncytio- and extravillous trophoblasts.
The receptors for these cytokines (except IL-31) share a common signal transducing subunit gp130 (IL6ST).
IL-6 is a critical regulator of the immune system and has been widely implicated in autoimmune disease, infection responses and in the regulation of metabolic, regenerative, and neural processes.
Species: Human
Natural/Endogenous Targets
Target
Interleukin-6 receptor
Interleukin-6 receptor, α subunit
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Interleukin-6 receptor, α subunit Hs Agonist Agonist 9.4 pKd - 10
pKd 9.4 (Kd 4.4x10-10 M) IL6R) expressed stably in murine NIH/3T3 fibroblasts.exhibited a single class of binding sites for 125I-labeled recombinant human interleukin-6 (125I-rhIL-6) (Kd = 440 pM, 20,000 receptors per cell). [10]
Interleukin-6 receptor Hs Agonist Agonist 9.4 pKd - 10
pKd 9.4 (Kd 4.4x10-10 M) Murine NIH/3T3 fibroblasts with human IL6R exhibited a single class of binding sites for 125I-labeled recombinant human interleukin-6 (125I-rhIL-6) (Kd = 440 pM, 20,000 receptors per cell). [10]
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
sirukumab Hs Antibody Binding 13.4 pKd - 1
pKd 13.4 (Kd 3.7x10-14 M) [1]
clazakizumab Hs Antibody Binding >10.3 pKd - 5
pKd >10.3 (Kd <5x10-11 M) [5]
siltuximab Hs Antibody Binding 10.2 pKd - 7
pKd 10.2 (Kd 5.7x10-11 M) [7]
olamkicept Hs None Binding 8.4 pKd - 9
pKd 8.4 (Kd 4.2x10-9 M) [9]
Description: Binding of hIL-6 to immobilized sgp130-Fc (olamkicept).