Quaternary Structure: Subunits

Oncostatin M-specific receptor, β subunit (Ligand-binding subunit)

Interleukin-6 receptor, β subunit (Other subunit)

Natural/Endogenous Ligands
oncostatin M {Sp: Human}

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Reference oncostatin M {Sp: Human} Hs Agonist - - ⤷

Immunopharmacology Comments

The oncostatin M receptor (from the OSMR gene) is a type I cytokine receptor. This protein heterodimerizes with the interleukin 6 signal transducer (IL6ST) to form the type II oncostatin M receptor, or with the interleukin 31 receptor α subunit (IL31RA) to form the IL-31 receptor. Germline mutations in OSMR underlie familial primary localized cutaneous amyloidosis [1], a finding that provides further understanding of the roles of oncostatin M and IL-31 in itch pathology.

Clinically-Relevant Mutations and Pathophysiology
Disease:  Primary cutaneous amyloidosis Description: A skin condition characterized by pruritus, skin scratching and by deposits of amyloid in the dermis. Synonyms: familial primary localized cutaneous amyloidosis Disease Ontology: DOID:0050639 Orphanet: ORPHA137807 Role:  Germline mutations in OSMR are reported to underlie PCA. References:  1-2