Quaternary Structure: Complexes

Interleukin-31 receptor

Oncostatin-M receptor

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	979	5p13.1	OSMR	oncostatin M receptor
Mouse	1	971	15 3.3 cM	Osmr	oncostatin M receptor
Rat	1	962	2q16	Osmr	oncostatin M receptor

Previous and Unofficial Names

IL-31 receptor subunit beta | IL-31RB | interleukin-31 receptor subunit beta | oncostatin M receptor | OSMRB

Database Links
Alphafold	Q99650 (Hs), O70458 (Mm), Q65Z14 (Rn)
CATH/Gene3D	2.60.40.10
ChEMBL Target	CHEMBL4630885 (Hs)
Ensembl Gene	ENSG00000145623 (Hs), ENSMUSG00000022146 (Mm), ENSRNOG00000033192 (Rn)
Entrez Gene	9180 (Hs), 18414 (Mm), 310132 (Rn)
Human Protein Atlas	ENSG00000145623 (Hs)
KEGG Gene	hsa:9180 (Hs), mmu:18414 (Mm), rno:310132 (Rn)
OMIM	601743 (Hs)
Pharos	Q99650 (Hs)
UniProtKB	Q99650 (Hs), O70458 (Mm), Q65Z14 (Rn)
Wikipedia	OSMR (Hs)

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Antibodies
Key to terms and symbols		Click column headers to sort
Antibody Sp. Action Value Parameter Reference vixarelimab Hs Binding - - 1 ⤷ [1]

Immunopharmacology Comments

Oncostatin M-specific receptor, β subunit (OSMR) is a component of two functional heterodimeric receptor complexes: 1. OSMR+ interleukin-6 receptor, β subunit (IL6ST) forms the receptor for oncostatin M 2. OSMR+ interleukin-31 receptor, α subunit forms the receptor for IL-31

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  Immune regulation

Immuno Process:  Cytokine production & signalling