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Interleukin 27 receptor, alpha

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2318

Nomenclature: Interleukin 27 receptor, alpha

Family: IL-6 receptor family

Quaternary Structure: Complexes
Interleukin-27 receptor
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 636 19p13.12 IL27RA interleukin 27 receptor subunit alpha
Mouse 1 623 8 C2 Il27ra interleukin 27 receptor, alpha
Rat - - 19q11 Il27ra interleukin 27 receptor subunit alpha
Previous and Unofficial Names Click here for help
WSX-1 | cytokine receptor-like 1 | IL-27RA | TCCR | interleukin 27 receptor, alpha | interleukin 27 receptor
Database Links Click here for help
Alphafold
CATH/Gene3D
Ensembl Gene
Human Protein Atlas
Pharos
UniProtKB
Wikipedia
Immunopharmacology Comments
This is the ligand binding subunit of the IL-27 receptor heterodimer, a complex with IL6ST (signal transducing subunit).
Immuno Process Associations
Immuno Process:  Chemotaxis & migration
Immuno Process:  Inflammation
Immuno Process:  T cell (activation)
Immuno Process:  B cell (activation)
Immuno Process:  Immune regulation
Immuno Process:  Immune system development
Immuno Process:  Cytokine production & signalling
Immuno Process:  Cellular signalling
Physiological Consequences of Altering Gene Expression Click here for help
MIce lacking Il27ra expression by their Treg cells develop more severe experimental autoimmune encephalomyelitis (EAE) than wild type mice, indicating that IL-27 is important for Treg function and control of autoimmunity.
Species:  Mouse
Tissue:  T regulatory cells.
Technique: 
References:  1

References

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1. Do J, Kim D, Kim S, Valentin-Torres A, Dvorina N, Jang E, Nagarajavel V, DeSilva TM, Li X, Ting AH et al.. (2017) Treg-specific IL-27Rα deletion uncovers a key role for IL-27 in Treg function to control autoimmunity. Proc Natl Acad Sci USA, 114 (38): 10190-10195. [PMID:28874534]

How to cite this page

IL-6 receptor family: Interleukin 27 receptor, alpha. Last modified on 18/09/2017. Accessed on 26/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2318.