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Interleukin-22 receptor α2

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1732

Nomenclature: Interleukin-22 receptor α2

Family: IL-10 receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 263 6q23.3 IL22RA2 interleukin 22 receptor subunit alpha 2
Mouse - 230 10 A3 Il22ra2 interleukin 22 receptor, alpha 2
Rat - 229 1p12 Il22ra2 interleukin 22 receptor subunit alpha 2
Previous and Unofficial Names Click here for help
CRF2-S1 | cytokine receptor family II soluble 1 | IL-22 receptor subunit alpha-2 | interleukin-22-binding protein | IL-22BP | interleukin 22 receptor, alpha 2 | interleukin 22 receptor
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
Immunopharmacology Comments
IL22RA2 (a.k.a. IL-22 binding protein) appears to act as a high affinity, soluble monomeric decoy receptor for IL-22 capable of neutralizeing the potent antimicrobial activity of IL-22 [1-2].
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
Immuno Process:  Inflammation
Immuno Process:  Immune regulation


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1. de Moura PR, Watanabe L, Bleicher L, Colau D, Dumoutier L, Lemaire MM, Renauld JC, Polikarpov I. (2009) Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22. FEBS Lett, 583 (7): 1072-7. [PMID:19285080]

2. Felix J, Savvides SN. (2017) Mechanisms of immunomodulation by mammalian and viral decoy receptors: insights from structures. Nat Rev Immunol, 17 (2): 112-129. [PMID:28028310]

How to cite this page

IL-10 receptor family: Interleukin-22 receptor α2. Last modified on 06/04/2017. Accessed on 24/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY,