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Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | 263 | 6q23.3 | IL22RA2 | interleukin 22 receptor subunit alpha 2 | |
| Mouse | - | 230 | 10 A3 | Il22ra2 | interleukin 22 receptor, alpha 2 | |
| Rat | - | 229 | 1p12 | Il22ra2 | interleukin 22 receptor subunit alpha 2 | |
| Previous and Unofficial Names |
| CRF2-S1 | cytokine receptor family II soluble 1 | IL-22 receptor subunit alpha-2 | interleukin-22-binding protein | IL-22BP | interleukin 22 receptor, alpha 2 | interleukin 22 receptor |
| Database Links |
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| Alphafold | Q969J5 (Hs), Q80XF5 (Mm), Q7TNI4 (Rn) |
| CATH/Gene3D | 2.60.40.10 |
| Ensembl Gene | ENSG00000164485 (Hs), ENSMUSG00000039760 (Mm), ENSRNOG00000012259 (Rn) |
| Entrez Gene | 116379 (Hs), 237310 (Mm), 444986 (Rn) |
| Human Protein Atlas | ENSG00000164485 (Hs) |
| KEGG Gene | hsa:116379 (Hs), mmu:237310 (Mm), rno:444986 (Rn) |
| OMIM | 606648 (Hs) |
| Pharos | Q969J5 (Hs) |
| UniProtKB | Q969J5 (Hs), Q80XF5 (Mm), Q7TNI4 (Rn) |
| Wikipedia | IL22RA2 (Hs) |
| Immunopharmacology Comments |
| IL22RA2 (a.k.a. IL-22 binding protein) appears to act as a high affinity, soluble monomeric decoy receptor for IL-22 capable of neutralizeing the potent antimicrobial activity of IL-22 [1-2]. |
| Immuno Process Associations | ||
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1. de Moura PR, Watanabe L, Bleicher L, Colau D, Dumoutier L, Lemaire MM, Renauld JC, Polikarpov I. (2009) Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22. FEBS Lett, 583 (7): 1072-7. [PMID:19285080]
2. Felix J, Savvides SN. (2017) Mechanisms of immunomodulation by mammalian and viral decoy receptors: insights from structures. Nat Rev Immunol, 17 (2): 112-129. [PMID:28028310]
IL-10 receptor family: Interleukin-22 receptor α2. Last modified on 06/04/2017. Accessed on 30/04/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1732.
target has curated data in GtoImmuPdb
