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pyrin and HIN domain family member 1

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2925

Nomenclature: pyrin and HIN domain family member 1

Abbreviated Name: PYHIN1

Family: Absent in melanoma (AIM)-like receptors (ALRs)

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 492 1q23.1 PYHIN1 pyrin and HIN domain family member 1
Gene and Protein Information Comments
Alternative transcription of the human gene gives rise to several protein isoforms: alpha 1 (presented here), alpha 2, beta a and beta 2. There are no mouse or rat homologs of human PYHIN1 with 1:1 orthology.
Previous and Unofficial Names Click here for help
IFIX i [2]
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Immunopharmacology Comments
PYHIN1 participates in the innate immune response to microbial DNA [1], and contributes to the induction of the interferon response to viral pathogens.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
Immuno Process:  Immune regulation
Immuno Process:  Inflammation
General Comments
PYHIN1 is a member of the ALR pattern recognition receptor family, a set of four related human genes classified by structural similarities as the Pyrin and HIN domain family (HGNC family 995). In addition to acting as a sensor of viral DNA, PYHIN1 also interacts with factors involved in transcriptional regulation and chromatin modulation [1].


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1. Diner BA, Li T, Greco TM, Crow MS, Fuesler JA, Wang J, Cristea IM. (2015) The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA. Mol Syst Biol, 11 (1): 787. [PMID:25665578]

2. Ding Y, Wang L, Su LK, Frey JA, Shao R, Hunt KK, Yan DH. (2004) Antitumor activity of IFIX, a novel interferon-inducible HIN-200 gene, in breast cancer. Oncogene, 23 (26): 4556-66. [PMID:15122330]

How to cite this page

Absent in melanoma (AIM)-like receptors (ALRs): pyrin and HIN domain family member 1. Last modified on 20/03/2017. Accessed on 24/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY,