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Non-catalytic pattern recognition receptors


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This section concentrates on those pattern recognition receptors (PRRs) encoded by the human genome which are non-catalytic DNA-sensing proteins. Like other PRRs, these proteins facilitate the induction of an innate immune response upon detection of pathogens, via a variety of signalling pathways.

Catalytic receptor PRRs included in the Guide To PHARMACOLOGY are:
Toll-like receptors (TLRs)
Nucleotide-binding oligomerization domain-like receptors (NLRs, also known as NOD-like receptors), and
RIG-I-like receptors (RLRs)

How to cite this family page

Database page citation:

Non-catalytic pattern recognition receptors. Accessed on 20/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.