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Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 1 | 1306 | 1q31.3-q32.1 | PTPRC | protein tyrosine phosphatase receptor type C | |
| Mouse | 1 | 1293 | 1 60.73 cM | Ptprc | protein tyrosine phosphatase receptor type C | |
| Rat | 1 | 1273 | 13q13 | Ptprc | protein tyrosine phosphatase, receptor type, C | |
| Previous and Unofficial Names |
| RT7 | protein tyrosine phosphatase, receptor type, C | T200 glycoprotein | CD45 | gp180 | LCA | Ly-5 | Lyt-4 | T200 leukocyte common antigen | protein tyrosine phosphatase | protein tyrosine phosphatase, receptor type C |
| Database Links |
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| Alphafold | P08575 (Hs), P06800 (Mm), P04157 (Rn) |
| CATH/Gene3D | 2.60.40.10, 3.90.190.10 |
| ChEMBL Target | CHEMBL3243 (Hs) |
| Ensembl Gene | ENSG00000081237 (Hs), ENSMUSG00000026395 (Mm), ENSRNOG00000000655 (Rn) |
| Entrez Gene | 5788 (Hs), 19264 (Mm), 24699 (Rn) |
| Human Protein Atlas | ENSG00000081237 (Hs) |
| KEGG Gene | hsa:5788 (Hs), mmu:19264 (Mm), rno:24699 (Rn) |
| OMIM | 151460 (Hs) |
| Pharos | P08575 (Hs) |
| UniProtKB | P08575 (Hs), P06800 (Mm), P04157 (Rn) |
| Wikipedia | PTPRC (Hs) |
| Natural/Endogenous Ligands |
| galectin-1 {Sp: Human} |
| Comments: Putative endogenous ligand. |
| Immunopharmacology Comments |
| CD45 is a high molecular weight cell surface glycoprotein expressed by cells of hematopoietic origin. Alternate transcripts lead to expression of isoforms that differ in their extracellular (ligand binding) domain (potentially facilitating differential and/or cell type specific biological functions [1]) but all contain the same intracellular domain that has tyrosine phosphatase activity. In relation to immune pathology, a single report from 1992 notes the presence of autoantibodies to CD45 in serum from patients with active systemic lupus erythematosus [2]. |
| Immuno Process Associations | ||
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1. Dalchau R, Fabre JW. (1981) Identification with a monoclonal antibody of a predominantly B lymphocyte-specific determinant of the human leukocyte common antigen. Evidence for structural and possible functional diversity of the human leukocyte common molecule. J Exp Med, 153 (4): 753-65. [PMID:6166706]
2. Winfield JB, Mimura T, Fernsten PD. (1992) Autoantibodies to CD45 in systemic lupus erythematosus. Int J Clin Lab Res, 21 (4): 292-5. [PMID:1534265]
Receptor tyrosine phosphatase (RTP) family: RTP Type C. Last modified on 19/04/2017. Accessed on 08/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1852.
target has curated data in GtoImmuPdb
