Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	80	6q21	CD24	CD24 molecule
Mouse	-	76	10 B2; 10 23.01 cM	Cd24a	CD24a antigen
Rat	-	76	20q13	Cd24	CD24 molecule

Database Links
Alphafold	P25063 (Hs), P24807 (Mm), Q07490 (Rn)
Ensembl Gene	ENSG00000272398 (Hs), ENSMUSG00000047139 (Mm), ENSRNOG00000000321 (Rn)
Entrez Gene	100133941 (Hs), 12484 (Mm), 25145 (Rn)
Human Protein Atlas	ENSG00000272398 (Hs)
KEGG Gene	hsa:100133941 (Hs), mmu:12484 (Mm), rno:25145 (Rn)
OMIM	600074 (Hs)
Pharos	P25063 (Hs)
RefSeq Nucleotide	NM_001291738 (Hs), NM_009846 (Mm), NM_012752 (Rn)
RefSeq Protein	NP_001278667 (Hs), NP_033976 (Mm), NP_036884 (Rn)
UniProtKB	P25063 (Hs), P24807 (Mm), Q07490 (Rn)
Wikipedia	CD24 (Hs)

Immunopharmacology Comments

CD24 is a small GPI-anchored sialoglycoprotein that is expressed by immune cells. It is involved in B cell and T cell functions. CD24 binds to SIGLEC10 in an interaction that selectively suppresses the immune response to danger-associated molecular patterns (DAMPs). This latter action is being exploited as a mechanism to reduce DAMP-induced inflammation in patients with COVID-19 and GvHD, using the CD24 mimetic MK-7110.

Cell Type Associations

Immuno Cell Type:  B cells Cell Ontology Term:   B cell (CL:0000236)

Immuno Cell Type:  T cells

Immuno Process Associations

Immuno Process:  Cellular signalling GO Annotations:  Associated to 3 GO processes GO:0002768 immune response-regulating cell surface receptor signaling pathway IC GO:0031295 T cell costimulation IDA GO:0042104 positive regulation of activated T cell proliferation IDA

Immuno Process:  Chemotaxis & migration GO Annotations:  Associated to 2 GO processes GO:0031295 T cell costimulation IDA GO:0042104 positive regulation of activated T cell proliferation IDA

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 2 GO processes GO:0001959 regulation of cytokine-mediated signaling pathway ISS GO:0032913 negative regulation of transforming growth factor beta3 production IMP

Immuno Process:  Immune regulation GO Annotations:  Associated to 3 GO processes GO:0002768 immune response-regulating cell surface receptor signaling pathway IC GO:0031295 T cell costimulation IDA GO:0042104 positive regulation of activated T cell proliferation IDA

Immuno Process:  T cell (activation) GO Annotations:  Associated to 2 GO processes GO:0031295 T cell costimulation IDA GO:0042104 positive regulation of activated T cell proliferation IDA