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CD24 molecule

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 3170

Nomenclature: CD24 molecule

Family: CD molecules

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 80 6q21 CD24 CD24 molecule
Mouse - 76 10 B2; 10 23.01 cM Cd24a CD24a antigen
Rat - 76 20q13 Cd24 CD24 molecule
Database Links Click here for help
Alphafold
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Immunopharmacology Comments
CD24 is a small GPI-anchored sialoglycoprotein that is expressed by immune cells. It is involved in B cell and T cell functions. CD24 binds to SIGLEC10 in an interaction that selectively suppresses the immune response to danger-associated molecular patterns (DAMPs). This latter action is being exploited as a mechanism to reduce DAMP-induced inflammation in patients with COVID-19 and GvHD, using the CD24 mimetic MK-7110.
Cell Type Associations
Immuno Cell Type:  B cells
Cell Ontology Term:   null (null)
Immuno Cell Type:  T cells
Immuno Process Associations
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 3 GO processes
GO:0002768 immune response-regulating cell surface receptor signaling pathway IC
GO:0031295 T cell costimulation IDA
GO:0042104 positive regulation of activated T cell proliferation IDA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 2 GO processes
GO:0031295 T cell costimulation IDA
GO:0042104 positive regulation of activated T cell proliferation IDA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 2 GO processes
GO:0001959 regulation of cytokine-mediated signaling pathway ISS
GO:0032913 negative regulation of transforming growth factor beta3 production IMP
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes
GO:0002768 immune response-regulating cell surface receptor signaling pathway IC
GO:0031295 T cell costimulation IDA
GO:0042104 positive regulation of activated T cell proliferation IDA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 2 GO processes
GO:0031295 T cell costimulation IDA
GO:0042104 positive regulation of activated T cell proliferation IDA

How to cite this page

CD molecules: CD24 molecule. Last modified on 28/01/2021. Accessed on 19/05/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3170.