Top ▲

ADAM8

Click here for help

Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1656

Nomenclature: ADAM8

Family: M12: Astacin/Adamalysin

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 824 10q26.3 ADAM8 ADAM metallopeptidase domain 8
Mouse 1 826 7 F4 Adam8 a disintegrin and metallopeptidase domain 8
Rat - - 1q41 Adam8 ADAM metallopeptidase domain 8
Previous and Unofficial Names Click here for help
Cell surface antigen MS2 | a disintegrin and metalloproteinase domain 8 | ADAM metallopeptidase domain 8 | CD156a
Database Links Click here for help
Specialist databases
MEROPS M12.208 (Hs)
Other databases
Alphafold P78325 (Hs), Q05910 (Mm)
BRENDA 3.4.24.-
CATH/Gene3D 3.40.390.10, 4.10.70.10
ChEMBL Target CHEMBL5665 (Hs)
Ensembl Gene ENSG00000151651 (Hs), ENSMUSG00000025473 (Mm), ENSRNOG00000017897 (Rn)
Entrez Gene 101 (Hs), 11501 (Mm), 499285 (Rn)
Human Protein Atlas ENSG00000151651 (Hs)
KEGG Enzyme 3.4.24.-
KEGG Gene hsa:101 (Hs), mmu:11501 (Mm), rno:499285 (Rn)
OMIM 602267 (Hs)
Pharos P78325 (Hs)
RefSeq Nucleotide NM_001109 (Hs), NM_001164490 (Hs), NM_001164489 (Hs), NM_007403 (Mm)
RefSeq Protein NP_001157962 (Hs), NP_001157961 (Hs), NP_001100 (Hs), NP_031429 (Mm)
UniProtKB P78325 (Hs), Q05910 (Mm)
Wikipedia ADAM8 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.24.-

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
INCB3619 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.0 pIC50 1
⤷ pIC50 6.0 (IC50 1x10-6 M) [1]
Immunopharmacology Comments
ADAM8 is reported to drive acute allergen-induced airway inflammation in a mouse model, and effect negated by ADAM8-deficiency (antibody-induced or gene knockout) [3]. The potential roles of ADAM8 in inflammation regulation and in experimental asthma are reviewed in [4] and [2] respectively.
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  T cell (activation)
Immuno Process:  Immune regulation
Immuno Process:  Immune system development
Immuno Process:  Cytokine production & signalling
Immuno Process:  Chemotaxis & migration
Immuno Process:  Cellular signalling

References

Show »

1. Georgiadis D, Yiotakis A. (2008) Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. Bioorg Med Chem, 16 (19): 8781-94. [PMID:18790648]

2. Matsuno O, Miyazaki E, Nureki S, Ueno T, Kumamoto T, Higuchi Y. (2006) Role of ADAM8 in experimental asthma. Immunol Lett, 102 (1): 67-73. [PMID:16154205]

3. Paulissen G, Rocks N, Guéders MM, Bedoret D, Crahay C, Quesada-Calvo F, Hacha J, Bekaert S, Desmet C, Foidart JM et al.. (2011) ADAM-8, a metalloproteinase, drives acute allergen-induced airway inflammation. Eur J Immunol, 41 (2): 380-91. [PMID:21268008]

4. Zarbock A, Rossaint J. (2011) Regulating inflammation: ADAM8--a new player in the game. Eur J Immunol, 41 (12): 3419-22. [PMID:22125009]

How to cite this page

M12: Astacin/Adamalysin: ADAM8. Last modified on 31/01/2017. Accessed on 18/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1656.