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receptor activator of NF-kappa B

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1881

Nomenclature: receptor activator of NF-kappa B

Abbreviated Name: RANK

Systematic Nomenclature: TNFRSF11A

Family: Tumour necrosis factor (TNF) receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 616 18q21.33 TNFRSF11A TNF receptor superfamily member 11a
Mouse 1 625 1 E2.1 Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Rat - - Tnfrsf11a TNF receptor superfamily member 11A
Previous and Unofficial Names Click here for help
CD265 | ODFR | osteoclast differentiation factor receptor | TRANCE-R | tumor necrosis factor receptor superfamily, member 11a, NFKB activator | tumor necrosis factor receptor superfamily, member 11a | tumor necrosis factor receptor superfamily member 11a | tumor necrosis factor receptor superfamily
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
Natural/Endogenous Ligands Click here for help
RANK ligand {Sp: Human}
Adaptor proteins (Human)
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
RANK ligand {Sp: Human} Peptide Ligand is endogenous in the given species Immunopharmacology Ligand Hs - - -
Immunopharmacology Comments
RANK is the receptor for RANK-ligand (RANKL). It is associated with immune cell function and lymph node development, in addition to bone remodeling and repair, thermal regulation, and mammary gland development. Signals to NF-κB and JNK via TRAF adaptor proteins.
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  T cell (activation)
Immuno Process:  B cell (activation)
Immuno Process:  Immune regulation
Immuno Process:  Immune system development
Immuno Process:  Cytokine production & signalling
Immuno Process:  Chemotaxis & migration


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