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butyrophilin like 3

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2944

Nomenclature: butyrophilin like 3

Family: Butyrophilin and butyrophilin-like proteins

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 466 5q35.3 BTNL3 butyrophilin like 3 3
Previous and Unofficial Names Click here for help
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Immunopharmacology Comments
BTNL3 and BTNL8 are two proteins expressed on the surface of human gut epithelial cells that are involved in shaping the constitution of gut resident dendritic γδ T cells [1]. γδ T cells in epithelial surfaces play a role in immunosurveillance and hence barrier integrity. Organ-specific expression of butyrophilin and butyrophilin-like proteins appears to be a conserved mechanism utilised by epithelia to shape local T cell compartments. Altered expression of BTNL genes has been associated with intestinal inflammation and colon cancer [2].
This protein contains an immunoglobulin (Ig)-like domain that resembles the antibody variable domain, that has been coined the 'V-set domain'. The genes for all human V-set domain containing proteins are listed in HGNC gene group 590.
Immuno Process Associations
Immuno Process:  Cellular signalling
Immuno Process:  Immune regulation


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1. Di Marco Barros R, Roberts NA, Dart RJ, Vantourout P, Jandke A, Nussbaumer O, Deban L, Cipolat S, Hart R, Iannitto ML et al.. (2016) Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments. Cell, 167 (1): 203-218.e17. [PMID:27641500]

2. Lebrero-Fernández C, Wenzel UA, Akeus P, Wang Y, Strid H, Simrén M, Gustavsson B, Börjesson LG, Cardell SL, Öhman L et al.. (2016) Altered expression of Butyrophilin (BTN) and BTN-like (BTNL) genes in intestinal inflammation and colon cancer. Immun Inflamm Dis, 4 (2): 191-200. [PMID:27957327]

3. Shibui A, Tsunoda T, Seki N, Suzuki Y, Sugano S, Sugane K. (1999) Cloning, expression analysis, and chromosomal localization of a novel butyrophilin-like receptor. J Hum Genet, 44 (4): 249-52. [PMID:10429365]

How to cite this page

Butyrophilin and butyrophilin-like proteins: butyrophilin like 3. Last modified on 07/08/2019. Accessed on 28/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY,